Serum factors from patients with systemic lupus erythematosus enhancing superoxide generation by normal neutrophils

M. Shingu, M. Oribe, T. Todoroki, K. Tatsukawa, K. Tomo-oka, M. Yasuda, M. Nobunaga

研究成果: Contribution to journalArticle査読

21 被引用数 (Scopus)

抄録

It has been suggested that human neutrophils exposed to preformed immune complexes or activated complement fragments generate O2- anions in extracellular medium. In vivo studies have revealed that oxygen intermediates produced by immune complex-activated neutrophils play an important role in subsequent tissue damage. Since it is difficult to obtain direct evidence that O2- is released into plasma in patients with systemic lupus erythematosus (SLE), we studied the capacities of their sera to stimulate O2- release by human neutrophils in vitro. Sera from patients with SLE significantly enhanced O2- generation by neutrophils compared to normal sera. The enhancing activity of serum in the induction of increased O2- generation correlated positively with the presence of serum immune complexes and negatively with serum complement levels. The enhancing factors were analyzed by serum fractionation on Sephadex G-200 gel filtration, and were concluded to be immune complexes of intermediate size containing an activated complement fragment.

本文言語英語
ページ(範囲)212-215
ページ数4
ジャーナルUnknown Journal
81
3
DOI
出版ステータス出版済み - 1983
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 皮膚病学
  • 細胞生物学

フィンガープリント

「Serum factors from patients with systemic lupus erythematosus enhancing superoxide generation by normal neutrophils」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル