Serum hyaluronic acid for the assessment of graft viability in porcine liver transplantation

Hidetoshi Itasaka, Keiji Kishikawa, Taketoshi Suehiro, Katsuhiko Yanaga, Mitsuo Shimada, Hidefumi Higashi, Saburo Kakizoe, Tetsuo Ikeda, Shigeki Wakiyama, Keizo Sugimachi

研究成果: Contribution to journalArticle査読

17 被引用数 (Scopus)


For the assessment of graft viability, serum hyaluronic acid (HA) levels during porcine orthotopic liver transplantation were measured in two groups: group 1 (viable:n = 5) in which allografts were transplanted following a minimal cold (4°C) preservation, and group 2 (nonviable:n = 4) in which allografts were transplanted after cold static storage (4°C) for 24 h in University of Wisconsin solution. The changes in the HA levels reached a significant difference between the two groups at 30 min after reperfusion (P < 0.02). In group 1, all animals survived for over 4 days, while all animals in group 2 died within 24 h. The serum HA also demonstrated a significant correlation with prothrombin time, ß-glucuronidase, and aspartate aminotransferase at 120 min after reperfusion. These results suggest that the measurement of serum HA is a potentially effective index for evaluating hepatic allograft viability.

ジャーナルSurgery today
出版ステータス出版済み - 8 1 1994

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