Serum interleukin-6 and fever at diagnosis in children with acute leukemia

Ikuko Minamishima, Shoichi Ohga, Eiichi Ishii, Akinobu Matsuzaki, Takeshi Kai, Kouhei Akazawa, Kohji Ueda

研究成果: ジャーナルへの寄稿編集

10 引用 (Scopus)

抄録

Patients and Methods: We examined serum interleukin (IL)-6 and tumor necrosis factor (TNF) a levels at initial diagnosis in acute leukemic children in order to clarify the roles of these cytokines on the febrile and hematological responses in the disease. Results: IL-6 levels were significantly higher in 34 leukemic children than in 18 healthy controls and 15 patients with various malignant diseases in long remission (p < 0.0001). Three patients with apparent bacterial infections showed especially high IL-6 levels of >100 pg/ml. In all the leukemic children, the high IL-6 levels at initial diagnosis had decreased to a low range at the time of complete remission, regardless of the use of antibiotics. In 10 of 14 leukemic children, TNF levels were high at diagnosis and then decreased to undetectable levels at remission. The relationship between IL-6/TNF levels and clinical/laboratory findings in leukemic children at diagnosis was also examined. Serum IL-6 significantly correlated with elevated body temperature (BT) (p < 0.001) and C-reac-tive protein (CRP) levels (p < 0.001), but not with other parameters such as leukocyte and platelet counts, hemoglobin levels, lactate dehydrogenase, and serum immuno-globulin. On the other hand, serum TNF did not show any statistical linkage with these parameters. Conclusion: These data provide evidence for the role of IL-6 in the pathogenesis of tumor-related fever and other acute phase responses in acute leukemia.

元の言語英語
ページ(範囲)239-244
ページ数6
ジャーナルJournal of Pediatric Hematology/Oncology
15
発行部数2
DOI
出版物ステータス出版済み - 1 1 1993

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Interleukin-6
Leukemia
Fever
Tumor Necrosis Factor-alpha
Serum
Serum Globulins
Acute-Phase Reaction
Body Temperature
Platelet Count
Leukocyte Count
L-Lactate Dehydrogenase
Hemoglobins
Cytokines
Anti-Bacterial Agents
Neoplasms
Proteins

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

これを引用

Serum interleukin-6 and fever at diagnosis in children with acute leukemia. / Minamishima, Ikuko; Ohga, Shoichi; Ishii, Eiichi; Matsuzaki, Akinobu; Kai, Takeshi; Akazawa, Kouhei; Ueda, Kohji.

:: Journal of Pediatric Hematology/Oncology, 巻 15, 番号 2, 01.01.1993, p. 239-244.

研究成果: ジャーナルへの寄稿編集

Minamishima, Ikuko ; Ohga, Shoichi ; Ishii, Eiichi ; Matsuzaki, Akinobu ; Kai, Takeshi ; Akazawa, Kouhei ; Ueda, Kohji. / Serum interleukin-6 and fever at diagnosis in children with acute leukemia. :: Journal of Pediatric Hematology/Oncology. 1993 ; 巻 15, 番号 2. pp. 239-244.
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abstract = "Patients and Methods: We examined serum interleukin (IL)-6 and tumor necrosis factor (TNF) a levels at initial diagnosis in acute leukemic children in order to clarify the roles of these cytokines on the febrile and hematological responses in the disease. Results: IL-6 levels were significantly higher in 34 leukemic children than in 18 healthy controls and 15 patients with various malignant diseases in long remission (p < 0.0001). Three patients with apparent bacterial infections showed especially high IL-6 levels of >100 pg/ml. In all the leukemic children, the high IL-6 levels at initial diagnosis had decreased to a low range at the time of complete remission, regardless of the use of antibiotics. In 10 of 14 leukemic children, TNF levels were high at diagnosis and then decreased to undetectable levels at remission. The relationship between IL-6/TNF levels and clinical/laboratory findings in leukemic children at diagnosis was also examined. Serum IL-6 significantly correlated with elevated body temperature (BT) (p < 0.001) and C-reac-tive protein (CRP) levels (p < 0.001), but not with other parameters such as leukocyte and platelet counts, hemoglobin levels, lactate dehydrogenase, and serum immuno-globulin. On the other hand, serum TNF did not show any statistical linkage with these parameters. Conclusion: These data provide evidence for the role of IL-6 in the pathogenesis of tumor-related fever and other acute phase responses in acute leukemia.",
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