Serum levels of Wisteria floribunda agglutinin-positive Mac-2 binding protein reflect the severity of chronic pancreatitis

Takashi Fujiyama, Tetsuhide Ito, Keijiro Ueda, Yuichi Tachibana, Kohei Yasunaga, Masami Miki, Takehiro Takaoka, Lingaku Lee, Ken Kawabe, Yoshihiro Ogawa

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

OBJECTIVES: To evaluate the utility of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA +-M2BP) level as a marker for chronic pancreatitis (CP). METHODS: We measured the serum WFA+-M2BP level of 74 patients with CP who had undergone endoscopic retrograde cholangiopancreatography and 30 normal controls (NC) using a glycan sugar chain-based immunoassay and investigated the relationship between serum WFA+-M2BP levels and the Cambridge classification of CP. RESULTS: Serum WFA+-M2BP level was significantly higher in patients with CP than in NC (0.64 ± 0.28 vs 0.34 ± 0.25, P < 0.001). The levels (expressed as cut-off index) of WFA+-M2BP for the classification of mild, moderate and marked CP were 0.44, 0.63 and 0.87, respectively. Thus, serum WFA+-M2BP levels increased with increasing CP severity. With a cut-off value of 0.34, 0.59 and 0.61, the area under the receiver operating characteristic curve, sensitivity and specificity were 0.829, 91.9% and 63.3% for mild CP; 0.891, 81.8% and 85.0% for moderate CP; and 0.888, 92.0% and 74.7% for marked CP, respectively. Multivariate analysis revealed that elevated serum WFA+-M2BP was independently associated with moderate and marked CP, respectively. CONCLUSION: Serum WFA+-M2BP level is a useful marker for grading CP severity.

元の言語英語
ページ(範囲)302-308
ページ数7
ジャーナルJournal of Digestive Diseases
18
発行部数5
DOI
出版物ステータス出版済み - 5 1 2017

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Chronic Pancreatitis
Carrier Proteins
Serum
wisteria lectin
Endoscopic Retrograde Cholangiopancreatography
Immunoassay
ROC Curve
Polysaccharides
Multivariate Analysis
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Serum levels of Wisteria floribunda agglutinin-positive Mac-2 binding protein reflect the severity of chronic pancreatitis. / Fujiyama, Takashi; Ito, Tetsuhide; Ueda, Keijiro; Tachibana, Yuichi; Yasunaga, Kohei; Miki, Masami; Takaoka, Takehiro; Lee, Lingaku; Kawabe, Ken; Ogawa, Yoshihiro.

:: Journal of Digestive Diseases, 巻 18, 番号 5, 01.05.2017, p. 302-308.

研究成果: ジャーナルへの寄稿記事

Fujiyama, T, Ito, T, Ueda, K, Tachibana, Y, Yasunaga, K, Miki, M, Takaoka, T, Lee, L, Kawabe, K & Ogawa, Y 2017, 'Serum levels of Wisteria floribunda agglutinin-positive Mac-2 binding protein reflect the severity of chronic pancreatitis', Journal of Digestive Diseases, 巻. 18, 番号 5, pp. 302-308. https://doi.org/10.1111/1751-2980.12475
Fujiyama, Takashi ; Ito, Tetsuhide ; Ueda, Keijiro ; Tachibana, Yuichi ; Yasunaga, Kohei ; Miki, Masami ; Takaoka, Takehiro ; Lee, Lingaku ; Kawabe, Ken ; Ogawa, Yoshihiro. / Serum levels of Wisteria floribunda agglutinin-positive Mac-2 binding protein reflect the severity of chronic pancreatitis. :: Journal of Digestive Diseases. 2017 ; 巻 18, 番号 5. pp. 302-308.
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abstract = "OBJECTIVES: To evaluate the utility of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA +-M2BP) level as a marker for chronic pancreatitis (CP). METHODS: We measured the serum WFA+-M2BP level of 74 patients with CP who had undergone endoscopic retrograde cholangiopancreatography and 30 normal controls (NC) using a glycan sugar chain-based immunoassay and investigated the relationship between serum WFA+-M2BP levels and the Cambridge classification of CP. RESULTS: Serum WFA+-M2BP level was significantly higher in patients with CP than in NC (0.64 ± 0.28 vs 0.34 ± 0.25, P < 0.001). The levels (expressed as cut-off index) of WFA+-M2BP for the classification of mild, moderate and marked CP were 0.44, 0.63 and 0.87, respectively. Thus, serum WFA+-M2BP levels increased with increasing CP severity. With a cut-off value of 0.34, 0.59 and 0.61, the area under the receiver operating characteristic curve, sensitivity and specificity were 0.829, 91.9{\%} and 63.3{\%} for mild CP; 0.891, 81.8{\%} and 85.0{\%} for moderate CP; and 0.888, 92.0{\%} and 74.7{\%} for marked CP, respectively. Multivariate analysis revealed that elevated serum WFA+-M2BP was independently associated with moderate and marked CP, respectively. CONCLUSION: Serum WFA+-M2BP level is a useful marker for grading CP severity.",
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T1 - Serum levels of Wisteria floribunda agglutinin-positive Mac-2 binding protein reflect the severity of chronic pancreatitis

AU - Fujiyama, Takashi

AU - Ito, Tetsuhide

AU - Ueda, Keijiro

AU - Tachibana, Yuichi

AU - Yasunaga, Kohei

AU - Miki, Masami

AU - Takaoka, Takehiro

AU - Lee, Lingaku

AU - Kawabe, Ken

AU - Ogawa, Yoshihiro

PY - 2017/5/1

Y1 - 2017/5/1

N2 - OBJECTIVES: To evaluate the utility of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA +-M2BP) level as a marker for chronic pancreatitis (CP). METHODS: We measured the serum WFA+-M2BP level of 74 patients with CP who had undergone endoscopic retrograde cholangiopancreatography and 30 normal controls (NC) using a glycan sugar chain-based immunoassay and investigated the relationship between serum WFA+-M2BP levels and the Cambridge classification of CP. RESULTS: Serum WFA+-M2BP level was significantly higher in patients with CP than in NC (0.64 ± 0.28 vs 0.34 ± 0.25, P < 0.001). The levels (expressed as cut-off index) of WFA+-M2BP for the classification of mild, moderate and marked CP were 0.44, 0.63 and 0.87, respectively. Thus, serum WFA+-M2BP levels increased with increasing CP severity. With a cut-off value of 0.34, 0.59 and 0.61, the area under the receiver operating characteristic curve, sensitivity and specificity were 0.829, 91.9% and 63.3% for mild CP; 0.891, 81.8% and 85.0% for moderate CP; and 0.888, 92.0% and 74.7% for marked CP, respectively. Multivariate analysis revealed that elevated serum WFA+-M2BP was independently associated with moderate and marked CP, respectively. CONCLUSION: Serum WFA+-M2BP level is a useful marker for grading CP severity.

AB - OBJECTIVES: To evaluate the utility of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA +-M2BP) level as a marker for chronic pancreatitis (CP). METHODS: We measured the serum WFA+-M2BP level of 74 patients with CP who had undergone endoscopic retrograde cholangiopancreatography and 30 normal controls (NC) using a glycan sugar chain-based immunoassay and investigated the relationship between serum WFA+-M2BP levels and the Cambridge classification of CP. RESULTS: Serum WFA+-M2BP level was significantly higher in patients with CP than in NC (0.64 ± 0.28 vs 0.34 ± 0.25, P < 0.001). The levels (expressed as cut-off index) of WFA+-M2BP for the classification of mild, moderate and marked CP were 0.44, 0.63 and 0.87, respectively. Thus, serum WFA+-M2BP levels increased with increasing CP severity. With a cut-off value of 0.34, 0.59 and 0.61, the area under the receiver operating characteristic curve, sensitivity and specificity were 0.829, 91.9% and 63.3% for mild CP; 0.891, 81.8% and 85.0% for moderate CP; and 0.888, 92.0% and 74.7% for marked CP, respectively. Multivariate analysis revealed that elevated serum WFA+-M2BP was independently associated with moderate and marked CP, respectively. CONCLUSION: Serum WFA+-M2BP level is a useful marker for grading CP severity.

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