Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure

Takaaki Furihata, Shintaro Kinugawa, Arata Fukushima, Shingo Takada, Tsuneaki Homma, Yoshihiro Masaki, Takahiro Abe, Takashi Yokota, Koji Oba, Koichi Okita, Hiroyuki Tsutsui

研究成果: ジャーナルへの寄稿記事

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Background It has been reported that skeletal muscle mass and strength are decreased in patients with heart failure (HF), and HF is associated with both reduced exercise capacity and adverse clinical outcomes. Myostatin has been known as a negative regulator of muscle growth, follistatin as the myostatin antagonist, maintaining tissue homeostasis. We thus determined serum myostatin levels in HF patients and whether they are associated with skeletal muscle wasting. Methods and results Forty one consecutive HF patients (58 ± 15 years old, New York Heart Association class I–III) and 30 age-matched healthy subjects as controls (53 ± 8 years old) were studied. Serum myostatin levels were significantly lower in HF patients than controls (18.7 ± 7.4 vs. 23.6 ± 5.2 ng/mL, P < 0.001). Circumference of the thickest part of the right thigh was significantly small (468 ± 72 vs. 559 ± 37 mm, P = 0.001) and lower extremity muscular strength was lower in patients with HF (129 ± 55 vs. 219 ± 52 N × m, P < 0.001). Fourteen HF patients (34%) had muscle wasting. By univariate analysis, higher age, higher serum follistatin, and lower serum myostatin were significantly associated with the presence of muscle wasting. By multivariate analysis, serum myostatin levels were independently associated with muscle wasting (OR = 0.77, 95% CI [0.58, 0.93], P = 0.02). Conclusion Serum myostatin levels were significantly decreased in HF patients and associated with lower extremity muscle wasting, suggesting that myostatin may be an important factor for maintaining skeletal muscle mass and strength in HF.

元の言語英語
ページ(範囲)483-487
ページ数5
ジャーナルInternational Journal of Cardiology
220
DOI
出版物ステータス出版済み - 10 1 2016
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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