Serum soluble ST2 as a marker of renal scar in pediatric upper urinary tract infection

Naoki Ohta, Hiroki Yasudo, Makoto Mizutani, Takeshi Matsushige, Reiji Fukano, Setsuaki Kittaka, Kenji Maehara, Kiyoshi Ichihara, Shoichi Ohga, Shunji Hasegawa

研究成果: ジャーナルへの寄稿記事

抄録

Background and objectives: Upper urinary tract infection is the most common serious bacterial infection in childhood. Patients with upper urinary tract infection have a risk for renal scarring with subsequent complications including hypertension, proteinuria, and progressive renal failure. However, the predictive biomarkers of renal scarring in children with upper urinary tract infection are still unknown. In this study, we evaluated whether soluble ST2 levels can be biomarkers of subsequent renal scarring in patients with upper urinary tract infection. Design, setting, participants, and measurements: We retrospectively studied pediatric patients with upper urinary tract infection at a tertiary center. Twenty-eight children had an upper urinary tract infection with (n = 14) and without (n = 14) renal scarring and underwent 99mtechnetium dimercaptosuccinic acid imaging. In addition, 13 control subjects were enrolled. The clinical data and serum cytokine levels, including soluble ST2 levels, were compared between those with and without renal scars. Results: Serum soluble ST2 levels were significantly higher in the scar group than in the non-scar group, whereas there was no difference in the levels of serum interferon-γ, interleukin-6, interleukin-10, soluble tumor necrosis factor receptor 1, and transforming growth factor-β between the scar and non-scar groups. The area under the curve for differentiating between the non-scar and scar groups on the basis of measurements of serum soluble ST2 was 0.79, with a sensitivity and specificity of 92.9% and 64.3%, respectively. Conclusion: These results suggest that serum soluble ST2 levels on admission could be a useful biomarker of subsequent renal scarring in pediatric patients with upper urinary tract infection.

元の言語英語
ページ(範囲)258-263
ページ数6
ジャーナルCytokine
120
DOI
出版物ステータス出版済み - 8 1 2019

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Pediatrics
Biomarkers
Urinary Tract Infections
Cicatrix
Kidney
Serum
Succimer
Tumor Necrosis Factor Receptors
Transforming Growth Factors
Interleukin-10
Interferons
Interleukin-6
Cytokines
Imaging techniques
Proteinuria
Bacterial Infections
Area Under Curve
Renal Insufficiency
Hypertension
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

これを引用

Ohta, N., Yasudo, H., Mizutani, M., Matsushige, T., Fukano, R., Kittaka, S., ... Hasegawa, S. (2019). Serum soluble ST2 as a marker of renal scar in pediatric upper urinary tract infection. Cytokine, 120, 258-263. https://doi.org/10.1016/j.cyto.2019.05.006

Serum soluble ST2 as a marker of renal scar in pediatric upper urinary tract infection. / Ohta, Naoki; Yasudo, Hiroki; Mizutani, Makoto; Matsushige, Takeshi; Fukano, Reiji; Kittaka, Setsuaki; Maehara, Kenji; Ichihara, Kiyoshi; Ohga, Shoichi; Hasegawa, Shunji.

:: Cytokine, 巻 120, 01.08.2019, p. 258-263.

研究成果: ジャーナルへの寄稿記事

Ohta, N, Yasudo, H, Mizutani, M, Matsushige, T, Fukano, R, Kittaka, S, Maehara, K, Ichihara, K, Ohga, S & Hasegawa, S 2019, 'Serum soluble ST2 as a marker of renal scar in pediatric upper urinary tract infection', Cytokine, 巻. 120, pp. 258-263. https://doi.org/10.1016/j.cyto.2019.05.006
Ohta N, Yasudo H, Mizutani M, Matsushige T, Fukano R, Kittaka S その他. Serum soluble ST2 as a marker of renal scar in pediatric upper urinary tract infection. Cytokine. 2019 8 1;120:258-263. https://doi.org/10.1016/j.cyto.2019.05.006
Ohta, Naoki ; Yasudo, Hiroki ; Mizutani, Makoto ; Matsushige, Takeshi ; Fukano, Reiji ; Kittaka, Setsuaki ; Maehara, Kenji ; Ichihara, Kiyoshi ; Ohga, Shoichi ; Hasegawa, Shunji. / Serum soluble ST2 as a marker of renal scar in pediatric upper urinary tract infection. :: Cytokine. 2019 ; 巻 120. pp. 258-263.
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abstract = "Background and objectives: Upper urinary tract infection is the most common serious bacterial infection in childhood. Patients with upper urinary tract infection have a risk for renal scarring with subsequent complications including hypertension, proteinuria, and progressive renal failure. However, the predictive biomarkers of renal scarring in children with upper urinary tract infection are still unknown. In this study, we evaluated whether soluble ST2 levels can be biomarkers of subsequent renal scarring in patients with upper urinary tract infection. Design, setting, participants, and measurements: We retrospectively studied pediatric patients with upper urinary tract infection at a tertiary center. Twenty-eight children had an upper urinary tract infection with (n = 14) and without (n = 14) renal scarring and underwent 99mtechnetium dimercaptosuccinic acid imaging. In addition, 13 control subjects were enrolled. The clinical data and serum cytokine levels, including soluble ST2 levels, were compared between those with and without renal scars. Results: Serum soluble ST2 levels were significantly higher in the scar group than in the non-scar group, whereas there was no difference in the levels of serum interferon-γ, interleukin-6, interleukin-10, soluble tumor necrosis factor receptor 1, and transforming growth factor-β between the scar and non-scar groups. The area under the curve for differentiating between the non-scar and scar groups on the basis of measurements of serum soluble ST2 was 0.79, with a sensitivity and specificity of 92.9{\%} and 64.3{\%}, respectively. Conclusion: These results suggest that serum soluble ST2 levels on admission could be a useful biomarker of subsequent renal scarring in pediatric patients with upper urinary tract infection.",
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AU - Yasudo, Hiroki

AU - Mizutani, Makoto

AU - Matsushige, Takeshi

AU - Fukano, Reiji

AU - Kittaka, Setsuaki

AU - Maehara, Kenji

AU - Ichihara, Kiyoshi

AU - Ohga, Shoichi

AU - Hasegawa, Shunji

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N2 - Background and objectives: Upper urinary tract infection is the most common serious bacterial infection in childhood. Patients with upper urinary tract infection have a risk for renal scarring with subsequent complications including hypertension, proteinuria, and progressive renal failure. However, the predictive biomarkers of renal scarring in children with upper urinary tract infection are still unknown. In this study, we evaluated whether soluble ST2 levels can be biomarkers of subsequent renal scarring in patients with upper urinary tract infection. Design, setting, participants, and measurements: We retrospectively studied pediatric patients with upper urinary tract infection at a tertiary center. Twenty-eight children had an upper urinary tract infection with (n = 14) and without (n = 14) renal scarring and underwent 99mtechnetium dimercaptosuccinic acid imaging. In addition, 13 control subjects were enrolled. The clinical data and serum cytokine levels, including soluble ST2 levels, were compared between those with and without renal scars. Results: Serum soluble ST2 levels were significantly higher in the scar group than in the non-scar group, whereas there was no difference in the levels of serum interferon-γ, interleukin-6, interleukin-10, soluble tumor necrosis factor receptor 1, and transforming growth factor-β between the scar and non-scar groups. The area under the curve for differentiating between the non-scar and scar groups on the basis of measurements of serum soluble ST2 was 0.79, with a sensitivity and specificity of 92.9% and 64.3%, respectively. Conclusion: These results suggest that serum soluble ST2 levels on admission could be a useful biomarker of subsequent renal scarring in pediatric patients with upper urinary tract infection.

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