Serum Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Biomarker for Incident Dementia

The Hisayama Study

Tomoyuki Ohara, Jun Hata, Masashi Tanaka, Takanori Honda, Hajime Yamakage, Daigo Yoshida, Takayuki Inoue, Yoichiro Hirakawa, Toru Kusakabe, Mao Shibata, Tadashi Teraoka, Takanari Kitazono, Shigenobu Kanba, Noriko Satoh-Asahara, Toshiharu Ninomiya

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Objective: To investigate the association between serum soluble triggering receptor expressed on myeloid cells 2 (sTREM2), a soluble type of an innate immune receptor expressed on the microglia, and the risk of dementia. Methods: A total of 1,349 Japanese community residents aged 60 and older without dementia were followed prospectively for 10 years (2002–2012). Serum sTREM2 levels were quantified by using an enzyme-linked immunosorbent assay and divided into quartiles. Cox proportional hazards model was used to estimate the hazard ratios (HRs) of serum sTREM2 levels on the risk of dementia. Results: During the follow-up, 300 subjects developed all-cause dementia; 193 had Alzheimer's disease (AD), and 85 had vascular dementia (VaD). The age- and sex-adjusted incidences of all-cause dementia, AD, and VaD elevated significantly with higher serum sTREM2 levels (all p for trend < 0.012). These associations were not altered after adjustment for confounding factors, including high-sensitive C-reactive protein. Subjects with the highest quartile of serum sTREM2 levels had significantly higher multivariable-adjusted risks of developing all-cause dementia, AD, and VaD than those with the lowest quartile (HR = 2.03, 95% confidence interval [CI] = 1.39–2.97, p < 0.001 for all-cause dementia; HR = 1.62, 95% CI = 1.02–2.55, p = 0.04 for AD; HR = 2.85, 95% CI = 1.35–6.02, p = 0.006 for VaD). No significant heterogeneity in the association of serum sTREM2 levels with the development of dementia was observed among the other risk factor subgroups (all p for heterogeneity > 0.11). Interpretation: The present findings suggest a significant association between increased serum sTREM2 levels and the risk of developing all-cause dementia, AD, and VaD in the general elderly Japanese population. ANN NEUROL 2019;85:47–58.

元の言語英語
ページ(範囲)47-58
ページ数12
ジャーナルAnnals of Neurology
85
発行部数1
DOI
出版物ステータス出版済み - 1 1 2019

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Myeloid Cells
Dementia
Biomarkers
Alzheimer Disease
Vascular Dementia
Serum
Microglia
Proportional Hazards Models
Enzyme-Linked Immunosorbent Assay
Incidence
Population

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

Serum Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Biomarker for Incident Dementia : The Hisayama Study. / Ohara, Tomoyuki; Hata, Jun; Tanaka, Masashi; Honda, Takanori; Yamakage, Hajime; Yoshida, Daigo; Inoue, Takayuki; Hirakawa, Yoichiro; Kusakabe, Toru; Shibata, Mao; Teraoka, Tadashi; Kitazono, Takanari; Kanba, Shigenobu; Satoh-Asahara, Noriko; Ninomiya, Toshiharu.

:: Annals of Neurology, 巻 85, 番号 1, 01.01.2019, p. 47-58.

研究成果: ジャーナルへの寄稿記事

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abstract = "Objective: To investigate the association between serum soluble triggering receptor expressed on myeloid cells 2 (sTREM2), a soluble type of an innate immune receptor expressed on the microglia, and the risk of dementia. Methods: A total of 1,349 Japanese community residents aged 60 and older without dementia were followed prospectively for 10 years (2002–2012). Serum sTREM2 levels were quantified by using an enzyme-linked immunosorbent assay and divided into quartiles. Cox proportional hazards model was used to estimate the hazard ratios (HRs) of serum sTREM2 levels on the risk of dementia. Results: During the follow-up, 300 subjects developed all-cause dementia; 193 had Alzheimer's disease (AD), and 85 had vascular dementia (VaD). The age- and sex-adjusted incidences of all-cause dementia, AD, and VaD elevated significantly with higher serum sTREM2 levels (all p for trend < 0.012). These associations were not altered after adjustment for confounding factors, including high-sensitive C-reactive protein. Subjects with the highest quartile of serum sTREM2 levels had significantly higher multivariable-adjusted risks of developing all-cause dementia, AD, and VaD than those with the lowest quartile (HR = 2.03, 95{\%} confidence interval [CI] = 1.39–2.97, p < 0.001 for all-cause dementia; HR = 1.62, 95{\%} CI = 1.02–2.55, p = 0.04 for AD; HR = 2.85, 95{\%} CI = 1.35–6.02, p = 0.006 for VaD). No significant heterogeneity in the association of serum sTREM2 levels with the development of dementia was observed among the other risk factor subgroups (all p for heterogeneity > 0.11). Interpretation: The present findings suggest a significant association between increased serum sTREM2 levels and the risk of developing all-cause dementia, AD, and VaD in the general elderly Japanese population. ANN NEUROL 2019;85:47–58.",
author = "Tomoyuki Ohara and Jun Hata and Masashi Tanaka and Takanori Honda and Hajime Yamakage and Daigo Yoshida and Takayuki Inoue and Yoichiro Hirakawa and Toru Kusakabe and Mao Shibata and Tadashi Teraoka and Takanari Kitazono and Shigenobu Kanba and Noriko Satoh-Asahara and Toshiharu Ninomiya",
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T1 - Serum Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Biomarker for Incident Dementia

T2 - The Hisayama Study

AU - Ohara, Tomoyuki

AU - Hata, Jun

AU - Tanaka, Masashi

AU - Honda, Takanori

AU - Yamakage, Hajime

AU - Yoshida, Daigo

AU - Inoue, Takayuki

AU - Hirakawa, Yoichiro

AU - Kusakabe, Toru

AU - Shibata, Mao

AU - Teraoka, Tadashi

AU - Kitazono, Takanari

AU - Kanba, Shigenobu

AU - Satoh-Asahara, Noriko

AU - Ninomiya, Toshiharu

PY - 2019/1/1

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