Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort

Satoshi Takeuchi, Norihiro Furusyo, Junya Ono, Yoshinori Azuma, Masaki Takemura, Hitokazu Esaki, Kazuhiko Yamamura, Yasutaka Mitamura, Gaku Tsuji, Mari Kiyomatsu-Oda, Jun Hayashi, Kenji Izuhara, Masutaka Furue

研究成果: ジャーナルへの寄稿記事

抄録

Background: We sometimes encounter difficulties in assessing the severity of pediatric atopic dermatitis (AD) using currently available biomarkers such as thymus and activation-regulated chemokine (TARC) due to the higher baseline values in non-AD children. Recent case control studies have indicated the usefulness of squamous cell carcinoma antigens (SCCAs) in pediatric and adult AD. Notably, SCCAs are induced by IL-4 and IL-13, vital Th2 cytokines that play important roles in AD etiology. Objectives: Relatively low prevalence and mild disease severity of pediatric AD are observed in our Ishigaki cohort presumably due to the moisturising subtropical climate, which could conversely mean possible higher allergic potential of non-AD subjects towards AD. Thus, the purpose of this study was to further investigate the feasibility of using SCCAs together with TARC and periostin as biomarkers for pediatric AD even in the Ishigaki cohort. Methods: We enrolled 1459 nursery school children and identified 96 as having AD through 2009–2011. As statistical analyses, we performed Student's t-test, correlation analysis, and receiver and operating characteristic (ROC) analysis. Results: Serum SCCA1, SCCA2, periostin and TARC levels were all significantly increased in AD compared with those in non-AD, but only serum SCCA2 showed a significant increase in AD when assessed in each age group or in subgroup analysis. Among the biomarkers tested, serum SCCA2 also showed the best correlations with clinical AD severity and TARC and showed the best diagnosability for AD in ROC analysis. Conclusions: SCCA2 is a potent biomarker for pediatric AD in the Ishigaki cohort.

元の言語英語
ページ(範囲)70-75
ページ数6
ジャーナルJournal of Dermatological Science
95
発行部数2
DOI
出版物ステータス出版済み - 8 2019

Fingerprint

Pediatrics
Atopic Dermatitis
Chemokine CCL17
Serum
Dermatitis
Biomarkers
ROC Curve
squamous cell carcinoma-related antigen
Nursery Schools
Interleukin-13
Climate
Interleukin-4
Case-Control Studies
Age Groups

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology

これを引用

Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort. / Takeuchi, Satoshi; Furusyo, Norihiro; Ono, Junya; Azuma, Yoshinori; Takemura, Masaki; Esaki, Hitokazu; Yamamura, Kazuhiko; Mitamura, Yasutaka; Tsuji, Gaku; Kiyomatsu-Oda, Mari; Hayashi, Jun; Izuhara, Kenji; Furue, Masutaka.

:: Journal of Dermatological Science, 巻 95, 番号 2, 08.2019, p. 70-75.

研究成果: ジャーナルへの寄稿記事

Takeuchi, S, Furusyo, N, Ono, J, Azuma, Y, Takemura, M, Esaki, H, Yamamura, K, Mitamura, Y, Tsuji, G, Kiyomatsu-Oda, M, Hayashi, J, Izuhara, K & Furue, M 2019, 'Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort', Journal of Dermatological Science, 巻. 95, 番号 2, pp. 70-75. https://doi.org/10.1016/j.jdermsci.2019.07.005
Takeuchi, Satoshi ; Furusyo, Norihiro ; Ono, Junya ; Azuma, Yoshinori ; Takemura, Masaki ; Esaki, Hitokazu ; Yamamura, Kazuhiko ; Mitamura, Yasutaka ; Tsuji, Gaku ; Kiyomatsu-Oda, Mari ; Hayashi, Jun ; Izuhara, Kenji ; Furue, Masutaka. / Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort. :: Journal of Dermatological Science. 2019 ; 巻 95, 番号 2. pp. 70-75.
@article{83663cb43ad447b598d78cf6342c577f,
title = "Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort",
abstract = "Background: We sometimes encounter difficulties in assessing the severity of pediatric atopic dermatitis (AD) using currently available biomarkers such as thymus and activation-regulated chemokine (TARC) due to the higher baseline values in non-AD children. Recent case control studies have indicated the usefulness of squamous cell carcinoma antigens (SCCAs) in pediatric and adult AD. Notably, SCCAs are induced by IL-4 and IL-13, vital Th2 cytokines that play important roles in AD etiology. Objectives: Relatively low prevalence and mild disease severity of pediatric AD are observed in our Ishigaki cohort presumably due to the moisturising subtropical climate, which could conversely mean possible higher allergic potential of non-AD subjects towards AD. Thus, the purpose of this study was to further investigate the feasibility of using SCCAs together with TARC and periostin as biomarkers for pediatric AD even in the Ishigaki cohort. Methods: We enrolled 1459 nursery school children and identified 96 as having AD through 2009–2011. As statistical analyses, we performed Student's t-test, correlation analysis, and receiver and operating characteristic (ROC) analysis. Results: Serum SCCA1, SCCA2, periostin and TARC levels were all significantly increased in AD compared with those in non-AD, but only serum SCCA2 showed a significant increase in AD when assessed in each age group or in subgroup analysis. Among the biomarkers tested, serum SCCA2 also showed the best correlations with clinical AD severity and TARC and showed the best diagnosability for AD in ROC analysis. Conclusions: SCCA2 is a potent biomarker for pediatric AD in the Ishigaki cohort.",
author = "Satoshi Takeuchi and Norihiro Furusyo and Junya Ono and Yoshinori Azuma and Masaki Takemura and Hitokazu Esaki and Kazuhiko Yamamura and Yasutaka Mitamura and Gaku Tsuji and Mari Kiyomatsu-Oda and Jun Hayashi and Kenji Izuhara and Masutaka Furue",
year = "2019",
month = "8",
doi = "10.1016/j.jdermsci.2019.07.005",
language = "English",
volume = "95",
pages = "70--75",
journal = "Journal of Dermatological Science",
issn = "0923-1811",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort

AU - Takeuchi, Satoshi

AU - Furusyo, Norihiro

AU - Ono, Junya

AU - Azuma, Yoshinori

AU - Takemura, Masaki

AU - Esaki, Hitokazu

AU - Yamamura, Kazuhiko

AU - Mitamura, Yasutaka

AU - Tsuji, Gaku

AU - Kiyomatsu-Oda, Mari

AU - Hayashi, Jun

AU - Izuhara, Kenji

AU - Furue, Masutaka

PY - 2019/8

Y1 - 2019/8

N2 - Background: We sometimes encounter difficulties in assessing the severity of pediatric atopic dermatitis (AD) using currently available biomarkers such as thymus and activation-regulated chemokine (TARC) due to the higher baseline values in non-AD children. Recent case control studies have indicated the usefulness of squamous cell carcinoma antigens (SCCAs) in pediatric and adult AD. Notably, SCCAs are induced by IL-4 and IL-13, vital Th2 cytokines that play important roles in AD etiology. Objectives: Relatively low prevalence and mild disease severity of pediatric AD are observed in our Ishigaki cohort presumably due to the moisturising subtropical climate, which could conversely mean possible higher allergic potential of non-AD subjects towards AD. Thus, the purpose of this study was to further investigate the feasibility of using SCCAs together with TARC and periostin as biomarkers for pediatric AD even in the Ishigaki cohort. Methods: We enrolled 1459 nursery school children and identified 96 as having AD through 2009–2011. As statistical analyses, we performed Student's t-test, correlation analysis, and receiver and operating characteristic (ROC) analysis. Results: Serum SCCA1, SCCA2, periostin and TARC levels were all significantly increased in AD compared with those in non-AD, but only serum SCCA2 showed a significant increase in AD when assessed in each age group or in subgroup analysis. Among the biomarkers tested, serum SCCA2 also showed the best correlations with clinical AD severity and TARC and showed the best diagnosability for AD in ROC analysis. Conclusions: SCCA2 is a potent biomarker for pediatric AD in the Ishigaki cohort.

AB - Background: We sometimes encounter difficulties in assessing the severity of pediatric atopic dermatitis (AD) using currently available biomarkers such as thymus and activation-regulated chemokine (TARC) due to the higher baseline values in non-AD children. Recent case control studies have indicated the usefulness of squamous cell carcinoma antigens (SCCAs) in pediatric and adult AD. Notably, SCCAs are induced by IL-4 and IL-13, vital Th2 cytokines that play important roles in AD etiology. Objectives: Relatively low prevalence and mild disease severity of pediatric AD are observed in our Ishigaki cohort presumably due to the moisturising subtropical climate, which could conversely mean possible higher allergic potential of non-AD subjects towards AD. Thus, the purpose of this study was to further investigate the feasibility of using SCCAs together with TARC and periostin as biomarkers for pediatric AD even in the Ishigaki cohort. Methods: We enrolled 1459 nursery school children and identified 96 as having AD through 2009–2011. As statistical analyses, we performed Student's t-test, correlation analysis, and receiver and operating characteristic (ROC) analysis. Results: Serum SCCA1, SCCA2, periostin and TARC levels were all significantly increased in AD compared with those in non-AD, but only serum SCCA2 showed a significant increase in AD when assessed in each age group or in subgroup analysis. Among the biomarkers tested, serum SCCA2 also showed the best correlations with clinical AD severity and TARC and showed the best diagnosability for AD in ROC analysis. Conclusions: SCCA2 is a potent biomarker for pediatric AD in the Ishigaki cohort.

UR - http://www.scopus.com/inward/record.url?scp=85071788040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071788040&partnerID=8YFLogxK

U2 - 10.1016/j.jdermsci.2019.07.005

DO - 10.1016/j.jdermsci.2019.07.005

M3 - Article

C2 - 31378660

AN - SCOPUS:85071788040

VL - 95

SP - 70

EP - 75

JO - Journal of Dermatological Science

JF - Journal of Dermatological Science

SN - 0923-1811

IS - 2

ER -