抄録
Background: Growing evidence suggests that high serum uric acid (SUA) levels are causally related to increased risk of chronic kidney disease (CKD). However, few studies have investigated the influence of elevated SUA levels on the incidence of kidney dysfunction and albuminuria separately in community-based populations. Methods and Results: A total of 2,059 community-dwelling Japanese subjects aged ≥40 years without CKD were followed for 5 years. CKD was defined as kidney dysfunction (estimated glomerular filtration rate <60 ml/min/1.73 m2) or albuminuria (urine albumin-creatinine ratio ≥30 mg/g). The odds ratio (OR) for the development of CKD was estimated according to quartiles of SUA (≤4.0, 4.1–4.9, 5.0–5.8, and ≥5.9 mg/dl). During the follow-up, 396 subjects developed CKD, of whom 125 had kidney dysfunction and 312 had albuminuria. The multivariable-adjusted risk of developing CKD increased with higher SUA levels (OR 1.00 [reference] for ≤4.0, 1.21 [95% confidence interval, 0.84–1.74] for 4.1–4.9, 1.47 [1.01–2.17] for 5.0–5.8, and 2.10 [1.37–3.23] for SUA ≥5.9 mg/dl, respectively). Similarly, there were positive associations between SUA level and the adjusted risk of developing kidney dysfunction (OR 1.00 [reference], 2.30 [1.10–4.82], 2.81 [1.34–5.88], and 3.73 [1.65–8.44]) and albuminuria (1.00 [reference], 1.12 [0.76–1.65], 1.35 [0.90–2.03], and 1.81 [1.14–2.87], respectively). Conclusions: Higher SUA levels were a significant risk factor for the development of both kidney dysfunction and albuminuria in a general Japanese population.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 1857-1862 |
| ページ数 | 6 |
| ジャーナル | Circulation Journal |
| 巻 | 80 |
| 発行部数 | 8 |
| DOI | |
| 出版物ステータス | 出版済み - 1 1 2016 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
これを引用
Serum uric acid as a risk factor for chronic kidney disease in a Japanese community-the hisayama study. / Takae, Keita; Nagata, Masaharu; Hata, Jun; Mukai, Naoko; Hirakawa, Yoichiro; Yoshida, Daigo; Kishimoto, Hiro; Tsuruya, Kazuhiko; Kitazono, Takanari; Kiyohara, Yutaka; Ninomiya, Toshiharu.
：: Circulation Journal, 巻 80, 番号 8, 01.01.2016, p. 1857-1862.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Serum uric acid as a risk factor for chronic kidney disease in a Japanese community-the hisayama study
AU - Takae, Keita
AU - Nagata, Masaharu
AU - Hata, Jun
AU - Mukai, Naoko
AU - Hirakawa, Yoichiro
AU - Yoshida, Daigo
AU - Kishimoto, Hiro
AU - Tsuruya, Kazuhiko
AU - Kitazono, Takanari
AU - Kiyohara, Yutaka
AU - Ninomiya, Toshiharu
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Background: Growing evidence suggests that high serum uric acid (SUA) levels are causally related to increased risk of chronic kidney disease (CKD). However, few studies have investigated the influence of elevated SUA levels on the incidence of kidney dysfunction and albuminuria separately in community-based populations. Methods and Results: A total of 2,059 community-dwelling Japanese subjects aged ≥40 years without CKD were followed for 5 years. CKD was defined as kidney dysfunction (estimated glomerular filtration rate <60 ml/min/1.73 m2) or albuminuria (urine albumin-creatinine ratio ≥30 mg/g). The odds ratio (OR) for the development of CKD was estimated according to quartiles of SUA (≤4.0, 4.1–4.9, 5.0–5.8, and ≥5.9 mg/dl). During the follow-up, 396 subjects developed CKD, of whom 125 had kidney dysfunction and 312 had albuminuria. The multivariable-adjusted risk of developing CKD increased with higher SUA levels (OR 1.00 [reference] for ≤4.0, 1.21 [95% confidence interval, 0.84–1.74] for 4.1–4.9, 1.47 [1.01–2.17] for 5.0–5.8, and 2.10 [1.37–3.23] for SUA ≥5.9 mg/dl, respectively). Similarly, there were positive associations between SUA level and the adjusted risk of developing kidney dysfunction (OR 1.00 [reference], 2.30 [1.10–4.82], 2.81 [1.34–5.88], and 3.73 [1.65–8.44]) and albuminuria (1.00 [reference], 1.12 [0.76–1.65], 1.35 [0.90–2.03], and 1.81 [1.14–2.87], respectively). Conclusions: Higher SUA levels were a significant risk factor for the development of both kidney dysfunction and albuminuria in a general Japanese population.
AB - Background: Growing evidence suggests that high serum uric acid (SUA) levels are causally related to increased risk of chronic kidney disease (CKD). However, few studies have investigated the influence of elevated SUA levels on the incidence of kidney dysfunction and albuminuria separately in community-based populations. Methods and Results: A total of 2,059 community-dwelling Japanese subjects aged ≥40 years without CKD were followed for 5 years. CKD was defined as kidney dysfunction (estimated glomerular filtration rate <60 ml/min/1.73 m2) or albuminuria (urine albumin-creatinine ratio ≥30 mg/g). The odds ratio (OR) for the development of CKD was estimated according to quartiles of SUA (≤4.0, 4.1–4.9, 5.0–5.8, and ≥5.9 mg/dl). During the follow-up, 396 subjects developed CKD, of whom 125 had kidney dysfunction and 312 had albuminuria. The multivariable-adjusted risk of developing CKD increased with higher SUA levels (OR 1.00 [reference] for ≤4.0, 1.21 [95% confidence interval, 0.84–1.74] for 4.1–4.9, 1.47 [1.01–2.17] for 5.0–5.8, and 2.10 [1.37–3.23] for SUA ≥5.9 mg/dl, respectively). Similarly, there were positive associations between SUA level and the adjusted risk of developing kidney dysfunction (OR 1.00 [reference], 2.30 [1.10–4.82], 2.81 [1.34–5.88], and 3.73 [1.65–8.44]) and albuminuria (1.00 [reference], 1.12 [0.76–1.65], 1.35 [0.90–2.03], and 1.81 [1.14–2.87], respectively). Conclusions: Higher SUA levels were a significant risk factor for the development of both kidney dysfunction and albuminuria in a general Japanese population.
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U2 - 10.1253/circj.CJ-16-0030
DO - 10.1253/circj.CJ-16-0030
M3 - Article
VL - 80
SP - 1857
EP - 1862
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 8
ER -