Serum vitamin B6, folate, and homocysteine concentrations and oxidative DNA damage in Japanese men and women

Keisuke Kuwahara, Akiko Nanri, Ngoc Minh Pham, Kayo Kurotani, Ayami Kume, Masao Sato, Kazuaki Kawai, Hiroshi Kasai, Tetsuya Mizoue

研究成果: ジャーナルへの寄稿学術誌査読

12 被引用数 (Scopus)

抄録

Objective: Higher vitamin B status has been linked to a lower risk for cancer, but the underlying mechanism remains elusive. The aim of the present study was to examine the association of pyridoxal, folate, and homocysteine (Hcy) with urinary 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative DNA damage. Methods: The participants were 500 employees (293 men and 207 women), ages 21 to 66 y, of two municipal offices in Japan. Serum pyridoxal and Hcy concentrations were measured using high-performance liquid chromatography (HPLC) method, and serum folate concentrations were measured using chemiluminescent immunoassay. Urinary 8-OHdG concentrations were measured using HPLC method. Multiple regression was used to estimate means of 8-OHdG for each tertile of pyridoxal, folate, and Hcy with adjustment for potential confounders. Results: In multivariate analysis, 8-OHdG concentration was inversely associated with pyridoxal concentration in men (P for trend = 0.045) but not in women. The association in men was confined to non-smokers (P for trend = 0.033) or those who consumed no or < 20 g/d of ethanol (P for trend = 0.048). 8-OHdG concentrations were not appreciably associated with folate and Hcy concentrations. Conclusion: The results suggest that vitamin B6, but not folate and homocysteine, plays a role against oxidative DNA damage in Japanese men.

本文言語英語
ページ(範囲)1219-1223
ページ数5
ジャーナルNutrition
29
10
DOI
出版ステータス出版済み - 10月 2013

!!!All Science Journal Classification (ASJC) codes

  • 内分泌学、糖尿病および代謝内科学
  • 栄養および糖尿病

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