Severity scores, itch scores and plasma substance P levels in atopic dermatitis treated with standard topical therapy with oral olopatadine hydrochloride

Chisato Hosokawa, Satoshi Takeuchi, Masutaka Furue

研究成果: ジャーナルへの寄稿学術誌査読

19 被引用数 (Scopus)

抄録

Atopic dermatitis (AD) is a common chronic or chronically relapsing, severely pruritic, eczematous skin disease. Recently, substance P (SP) has been demonstrated to be one of the important neuropeptides for mediating itch-scratch and stress-scratch cycles. In this study, we examined the severity scores, itch scores and plasma SP levels in 19 patients with AD treated with standard topical therapy with or without an oral antihistamine, olopatadine hydrochloride, for 4 weeks. The standard therapy decreased SCORAD scores, itch behavioral rating scores and plasma SP levels at post-treatment in the mass, but the topical therapy with olopatadine was more effective than the topical therapy alone, suggesting a potential additive effect.

本文言語英語
ページ(範囲)185-190
ページ数6
ジャーナルJournal of Dermatology
36
4
DOI
出版ステータス出版済み - 4月 2009

!!!All Science Journal Classification (ASJC) codes

  • 皮膚病学

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