In some cases of intoxication with dioxins and dioxin-related compounds such as Yu-cheng, Seveso, Russian and Austrian chloracne cohorts, there was a significant reduction in the male-to-female sex ratio in children born to men who had been exposed to dioxins and dioxin-related compounds before age 20 years or in their early 20s. The aim of this study was to ascertain whether parental exposure to dioxin-related compounds at a particular age affected the sex of subsequent offspring in Yusho. Maternal exposure had no significant effect on the sex ratio of the offspring. The sex ratio of children born to men exposed before age 20, men exposed after age 20, or to parents who were both exposed were not significantly different from the expected sex ratio of 0.514.
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