SF-1 expression during adrenal development and tumourigenesis

Jennifer R. Gardiner, Yuichi Shima, Ken ichirou Morohashi, Amanda Swain

研究成果: ジャーナルへの寄稿総説査読

16 被引用数 (Scopus)

抄録

SF-1 is a master regulator of steroidogenesis whose expression is critical for normal adrenal and gonadal organogenesis. Strict maintenance of SF-1 levels is essential, and mutations causing under- or overexpression result in congenital adrenal and gonadal defects or hyperplasia, respectively. Data from transgenic mouse models points to a network of transcription factors responsible for stringent regulation of . Sf-1 expression during development, which bind to intronic enhancer elements in addition to the basal promoter to specifically modulate transcription in each . Sf-1-expressing tissue. Furthermore, analysis of the role of SF-1 in adrenal tumourigenesis implies that improper developmental regulation of . Sf-1 expression may have postnatal consequences separate from the well-documented developmental defects.

本文言語英語
ページ(範囲)12-18
ページ数7
ジャーナルMolecular and Cellular Endocrinology
351
1
DOI
出版ステータス出版済み - 3月 31 2012

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 内分泌学

フィンガープリント

「SF-1 expression during adrenal development and tumourigenesis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル