SF-1 expression during adrenal development and tumourigenesis

Jennifer R. Gardiner, Yuichi Shima, Ken-Ichirou Morohashi, Amanda Swain

研究成果: ジャーナルへの寄稿評論記事

14 引用 (Scopus)

抄録

SF-1 is a master regulator of steroidogenesis whose expression is critical for normal adrenal and gonadal organogenesis. Strict maintenance of SF-1 levels is essential, and mutations causing under- or overexpression result in congenital adrenal and gonadal defects or hyperplasia, respectively. Data from transgenic mouse models points to a network of transcription factors responsible for stringent regulation of . Sf-1 expression during development, which bind to intronic enhancer elements in addition to the basal promoter to specifically modulate transcription in each . Sf-1-expressing tissue. Furthermore, analysis of the role of SF-1 in adrenal tumourigenesis implies that improper developmental regulation of . Sf-1 expression may have postnatal consequences separate from the well-documented developmental defects.

元の言語英語
ページ(範囲)12-18
ページ数7
ジャーナルMolecular and Cellular Endocrinology
351
発行部数1
DOI
出版物ステータス出版済み - 3 31 2012

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Organogenesis
Transgenic Mice
Hyperplasia
Transcription Factors
Maintenance
Defects
Mutation
Transcription
Tissue

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Molecular Biology
  • Biochemistry

これを引用

SF-1 expression during adrenal development and tumourigenesis. / Gardiner, Jennifer R.; Shima, Yuichi; Morohashi, Ken-Ichirou; Swain, Amanda.

:: Molecular and Cellular Endocrinology, 巻 351, 番号 1, 31.03.2012, p. 12-18.

研究成果: ジャーナルへの寄稿評論記事

Gardiner, Jennifer R. ; Shima, Yuichi ; Morohashi, Ken-Ichirou ; Swain, Amanda. / SF-1 expression during adrenal development and tumourigenesis. :: Molecular and Cellular Endocrinology. 2012 ; 巻 351, 番号 1. pp. 12-18.
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