Sfrp 1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis

Wataru Satoh, Takafumi Gotoh, Yasuhiko Tsunematsu, Shinichi Aizawa, Akihiko Shimon

研究成果: ジャーナルへの寄稿学術誌査読

108 被引用数 (Scopus)

抄録

Regulation of Wnt signaling is essential for embryonic patterning. Sfrps are secreted Wnt antagonists that directly interact with the Wnt ligand to inhibit signaling. Here, we show that Sfrp1 and Sfrp2 are required for anteroposterior (AP) axis elongation and somitogenesis in the thoracic region during mouse embryogenesis. Double homozygous mutations in Sfrp1 and Sfrp2 lead to severe shortening of the thoracic region. By contrast, a homozygous mutation in one or the other exerts no effect on embryogenesis, indicating that Sfrp1 and Sfrp2 are functionally redundant. The defect of a shortened thoracic region appears to be the consequence of AP axis reduction and incomplete somite segmentation. The reduction in the AP axis is partially due to abnormalities in cell migration of pre-somitic mesoderm from the end of gastrulation. Aberrant somite segmentation is associated with altered oscillations of Notch signaling, as evidenced by abnormal Lfng and Hes7 expression during somitogenesis in the thoracic region. This study suggests that Wnt regulation by Sfrp1 and Sfrp2 is required for embryonic patterning.

本文言語英語
ページ(範囲)989-999
ページ数11
ジャーナルDevelopment
133
6
DOI
出版ステータス出版済み - 3月 1 2006

!!!All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 発生生物学

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