SHED repair critical-size calvarial defects in mice

B. M. Seo, W. Sonoyama, T. Yamaza, C. Coppe, T. Kikuiri, K. Akiyama, J. S. Lee, S. Shi

研究成果: ジャーナルへの寄稿学術誌査読

189 被引用数 (Scopus)

抄録

Objective: Stem cells from human exfoliated deciduous teeth (SHED) are a population of highly proliferative postnatal stem cells capable of differentiating into odontoblasts, adipocytes, neural cells, and osteo-inductive cells. To examine whether SHED-mediated bone regeneration can be utilized for therapeutic purposes, we used SHED to repair critical-size calvarial defects in immunocompromised mice. Materials and methods: We generated calvarial defects and transplanted SHED with hydroxyapatite/tricalcium phosphate as a carrier into the defect areas. Results: SHED were able to repair the defects with substantial bone formation. Interestingly, SHED-mediated osteogenesis failed to recruit hematopoietic marrow elements that are commonly seen in bone marrow mesenchymal stem cell-generated bone. Furthermore, SHED were found to co-express mesenchymal stem cell marker, CC9/MUC18/CD146, with an array of growth factor receptors such as transforming growth factor β receptor I and II, fibroblast growth factor receptor I and III, and vascular endothelial growth factor receptor I, implying their comprehensive differentiation potential. Conclusions: Our data indicate that SHED, derived from neural crest cells, may select unique mechanisms to exert osteogenesis. SHED might be a suitable resource for orofacial bone regeneration.

本文言語英語
ページ(範囲)428-434
ページ数7
ジャーナルOral Diseases
14
5
DOI
出版ステータス出版済み - 7月 2008
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 耳鼻咽喉科学
  • 歯科学(全般)

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