Short- and long-term outcomes of endoscopic resection of rectal neuroendocrine tumours

Analyses according to the WHO 2010 classification

Kazuhiko Nakamura, Mikako Osada, Ayako Goto, tsutomu iwasa, Shunsuke Takahashi, Nobuyoshi Takizawa, Kazuya Akahoshi, Toshiaki Ochiai, Norimoto Nakamura, Hirotada Akiho, Soichi Itaba, Naohiko Harada, Moritomo Iju, Munehiro Tanaka, Hiroaki Kubo, Shinichi Somada, Eikichi Ihara, Yoshinao Oda, Tetsuhide Ito, Ryoichi Takayanagi

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

抄録

Objective Although the World Health Organisation (WHO) defined a novel classification of gastroenteropancreatic neuroendocrine tumours (NETs) in 2010, indications for endoscopic resection of rectal NETs in the guidelines were based on evidence accumulated for carcinoid tumours defined by a previous classification. This study was designed to clarify indications for endoscopic resection of rectal NETs corresponding to the new WHO classifications. Material and methods One hundred-seventy rectal NETs resected endoscopically from April 2001 to March 2012 were histologically re-classified according to the WHO 2010 criteria. The clinicopathological features of these lesions were analysed, and the short- and long-term outcomes of endoscopic resection were evaluated. Results Of the 170 rectal NETs, 166 were histopathologically diagnosed as NET G1 and four as NET G2. Thirty-eight tumours (22.4%) were positive for lymphovascular invasion, a percentage higher than expected. Although the curative resection rate was low (65.3%), en bloc (98.8%) and complete (85.9%) resection rates were high. Modified endoscopic mucosal resection (88.0%) and endoscopic submucosal dissection (92.2%) resulted in significantly higher complete resection rates than conventional endoscopic mucosal resection (36.4%). No patient experienced tumour recurrence, despite the low curative resection rate. Conclusion Despite the low curative resection rate, prognosis after endoscopic resection of rectal NETs was excellent. Prospective large-scale, long-term studies are required to determine whether NET G2 and tumours >1 cm should be included in the indication for endoscopic resection and whether tumours with lymphovascular invasion can be followed up without additional surgery.

元の言語英語
ページ(範囲)448-455
ページ数8
ジャーナルScandinavian Journal of Gastroenterology
51
発行部数4
DOI
出版物ステータス出版済み - 4 2 2016

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Neuroendocrine Tumors
Rectal Neoplasms
Neoplasms
Carcinoid Tumor
Guidelines
Recurrence

All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Short- and long-term outcomes of endoscopic resection of rectal neuroendocrine tumours : Analyses according to the WHO 2010 classification. / Nakamura, Kazuhiko; Osada, Mikako; Goto, Ayako; iwasa, tsutomu; Takahashi, Shunsuke; Takizawa, Nobuyoshi; Akahoshi, Kazuya; Ochiai, Toshiaki; Nakamura, Norimoto; Akiho, Hirotada; Itaba, Soichi; Harada, Naohiko; Iju, Moritomo; Tanaka, Munehiro; Kubo, Hiroaki; Somada, Shinichi; Ihara, Eikichi; Oda, Yoshinao; Ito, Tetsuhide; Takayanagi, Ryoichi.

:: Scandinavian Journal of Gastroenterology, 巻 51, 番号 4, 02.04.2016, p. 448-455.

研究成果: ジャーナルへの寄稿記事

Nakamura, K, Osada, M, Goto, A, iwasa, T, Takahashi, S, Takizawa, N, Akahoshi, K, Ochiai, T, Nakamura, N, Akiho, H, Itaba, S, Harada, N, Iju, M, Tanaka, M, Kubo, H, Somada, S, Ihara, E, Oda, Y, Ito, T & Takayanagi, R 2016, 'Short- and long-term outcomes of endoscopic resection of rectal neuroendocrine tumours: Analyses according to the WHO 2010 classification', Scandinavian Journal of Gastroenterology, 巻. 51, 番号 4, pp. 448-455. https://doi.org/10.3109/00365521.2015.1107752
Nakamura, Kazuhiko ; Osada, Mikako ; Goto, Ayako ; iwasa, tsutomu ; Takahashi, Shunsuke ; Takizawa, Nobuyoshi ; Akahoshi, Kazuya ; Ochiai, Toshiaki ; Nakamura, Norimoto ; Akiho, Hirotada ; Itaba, Soichi ; Harada, Naohiko ; Iju, Moritomo ; Tanaka, Munehiro ; Kubo, Hiroaki ; Somada, Shinichi ; Ihara, Eikichi ; Oda, Yoshinao ; Ito, Tetsuhide ; Takayanagi, Ryoichi. / Short- and long-term outcomes of endoscopic resection of rectal neuroendocrine tumours : Analyses according to the WHO 2010 classification. :: Scandinavian Journal of Gastroenterology. 2016 ; 巻 51, 番号 4. pp. 448-455.
@article{a69ab492fd9843e6bef723c69c2ee3d6,
title = "Short- and long-term outcomes of endoscopic resection of rectal neuroendocrine tumours: Analyses according to the WHO 2010 classification",
abstract = "Objective Although the World Health Organisation (WHO) defined a novel classification of gastroenteropancreatic neuroendocrine tumours (NETs) in 2010, indications for endoscopic resection of rectal NETs in the guidelines were based on evidence accumulated for carcinoid tumours defined by a previous classification. This study was designed to clarify indications for endoscopic resection of rectal NETs corresponding to the new WHO classifications. Material and methods One hundred-seventy rectal NETs resected endoscopically from April 2001 to March 2012 were histologically re-classified according to the WHO 2010 criteria. The clinicopathological features of these lesions were analysed, and the short- and long-term outcomes of endoscopic resection were evaluated. Results Of the 170 rectal NETs, 166 were histopathologically diagnosed as NET G1 and four as NET G2. Thirty-eight tumours (22.4{\%}) were positive for lymphovascular invasion, a percentage higher than expected. Although the curative resection rate was low (65.3{\%}), en bloc (98.8{\%}) and complete (85.9{\%}) resection rates were high. Modified endoscopic mucosal resection (88.0{\%}) and endoscopic submucosal dissection (92.2{\%}) resulted in significantly higher complete resection rates than conventional endoscopic mucosal resection (36.4{\%}). No patient experienced tumour recurrence, despite the low curative resection rate. Conclusion Despite the low curative resection rate, prognosis after endoscopic resection of rectal NETs was excellent. Prospective large-scale, long-term studies are required to determine whether NET G2 and tumours >1 cm should be included in the indication for endoscopic resection and whether tumours with lymphovascular invasion can be followed up without additional surgery.",
author = "Kazuhiko Nakamura and Mikako Osada and Ayako Goto and tsutomu iwasa and Shunsuke Takahashi and Nobuyoshi Takizawa and Kazuya Akahoshi and Toshiaki Ochiai and Norimoto Nakamura and Hirotada Akiho and Soichi Itaba and Naohiko Harada and Moritomo Iju and Munehiro Tanaka and Hiroaki Kubo and Shinichi Somada and Eikichi Ihara and Yoshinao Oda and Tetsuhide Ito and Ryoichi Takayanagi",
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TY - JOUR

T1 - Short- and long-term outcomes of endoscopic resection of rectal neuroendocrine tumours

T2 - Analyses according to the WHO 2010 classification

AU - Nakamura, Kazuhiko

AU - Osada, Mikako

AU - Goto, Ayako

AU - iwasa, tsutomu

AU - Takahashi, Shunsuke

AU - Takizawa, Nobuyoshi

AU - Akahoshi, Kazuya

AU - Ochiai, Toshiaki

AU - Nakamura, Norimoto

AU - Akiho, Hirotada

AU - Itaba, Soichi

AU - Harada, Naohiko

AU - Iju, Moritomo

AU - Tanaka, Munehiro

AU - Kubo, Hiroaki

AU - Somada, Shinichi

AU - Ihara, Eikichi

AU - Oda, Yoshinao

AU - Ito, Tetsuhide

AU - Takayanagi, Ryoichi

PY - 2016/4/2

Y1 - 2016/4/2

N2 - Objective Although the World Health Organisation (WHO) defined a novel classification of gastroenteropancreatic neuroendocrine tumours (NETs) in 2010, indications for endoscopic resection of rectal NETs in the guidelines were based on evidence accumulated for carcinoid tumours defined by a previous classification. This study was designed to clarify indications for endoscopic resection of rectal NETs corresponding to the new WHO classifications. Material and methods One hundred-seventy rectal NETs resected endoscopically from April 2001 to March 2012 were histologically re-classified according to the WHO 2010 criteria. The clinicopathological features of these lesions were analysed, and the short- and long-term outcomes of endoscopic resection were evaluated. Results Of the 170 rectal NETs, 166 were histopathologically diagnosed as NET G1 and four as NET G2. Thirty-eight tumours (22.4%) were positive for lymphovascular invasion, a percentage higher than expected. Although the curative resection rate was low (65.3%), en bloc (98.8%) and complete (85.9%) resection rates were high. Modified endoscopic mucosal resection (88.0%) and endoscopic submucosal dissection (92.2%) resulted in significantly higher complete resection rates than conventional endoscopic mucosal resection (36.4%). No patient experienced tumour recurrence, despite the low curative resection rate. Conclusion Despite the low curative resection rate, prognosis after endoscopic resection of rectal NETs was excellent. Prospective large-scale, long-term studies are required to determine whether NET G2 and tumours >1 cm should be included in the indication for endoscopic resection and whether tumours with lymphovascular invasion can be followed up without additional surgery.

AB - Objective Although the World Health Organisation (WHO) defined a novel classification of gastroenteropancreatic neuroendocrine tumours (NETs) in 2010, indications for endoscopic resection of rectal NETs in the guidelines were based on evidence accumulated for carcinoid tumours defined by a previous classification. This study was designed to clarify indications for endoscopic resection of rectal NETs corresponding to the new WHO classifications. Material and methods One hundred-seventy rectal NETs resected endoscopically from April 2001 to March 2012 were histologically re-classified according to the WHO 2010 criteria. The clinicopathological features of these lesions were analysed, and the short- and long-term outcomes of endoscopic resection were evaluated. Results Of the 170 rectal NETs, 166 were histopathologically diagnosed as NET G1 and four as NET G2. Thirty-eight tumours (22.4%) were positive for lymphovascular invasion, a percentage higher than expected. Although the curative resection rate was low (65.3%), en bloc (98.8%) and complete (85.9%) resection rates were high. Modified endoscopic mucosal resection (88.0%) and endoscopic submucosal dissection (92.2%) resulted in significantly higher complete resection rates than conventional endoscopic mucosal resection (36.4%). No patient experienced tumour recurrence, despite the low curative resection rate. Conclusion Despite the low curative resection rate, prognosis after endoscopic resection of rectal NETs was excellent. Prospective large-scale, long-term studies are required to determine whether NET G2 and tumours >1 cm should be included in the indication for endoscopic resection and whether tumours with lymphovascular invasion can be followed up without additional surgery.

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DO - 10.3109/00365521.2015.1107752

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JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

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