Short poly-glutamine repeat in the androgen receptor in New World monkeys

Chihiro Hiramatsu, Annika Paukner, Hika Kuroshima, Kazuo Fujita, Stephen J. Suomi, Miho Inoue-Murayama

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)

抄録

The androgen receptor mediates various physiological and developmental functions and is highly conserved in mammals. Although great intraspecific length polymorphisms in poly glutamine (poly-Q) and poly glycine (poly-G) regions of the androgen receptor in humans, apes and several Old World monkeys have been reported, little is known about the characteristics of these regions in New World monkeys. In this study, we surveyed 17 species of New World monkeys and found length polymorphisms in these regions in three species (common squirrel monkeys, tufted capuchin monkeys and owl monkeys). We found that the poly-Q region in New World monkeys is relatively shorter than that in catarrhines (humans, apes and Old World monkeys). In addition, we observed that codon usage for poly-G region in New World monkeys is unique among primates. These results suggest that the length of polymorphic regions in androgen receptor genes have evolved uniquely in New World monkeys.

本文言語英語
ページ(範囲)105-113
ページ数9
ジャーナルMeta Gene
14
DOI
出版ステータス出版済み - 12月 2017

!!!All Science Journal Classification (ASJC) codes

  • 遺伝学
  • 遺伝学(臨床)

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