Short-term and low-dose prednisolone administration reduces aromatase inhibitor-induced arthralgia in patients with breast cancer

Makoto Kubo, Hideya Onishi, Syoji Kuroki, Masayuki Okido, Kazuo Shimada, Kazunori Yokohata, Shuyo Umeda, Takahiro Ogawa, Masao Tanaka, Mitsuo Katano

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

抜粋

Aromatase inhibitors (AIs) are important therapeutic drugs for postmenopausal women with hormone receptor-positive breast cancer. However, adverse effects of AIs such as arthralgia have been extensively reported. We performed a joint prospective, multi-institutional investigation to find out whether a low-dose and short-term prednisolone is effective against AI-induced arthralgia in 27 patients with breast cancer. Patients were administered 5 mg of oral prednisolone once a day in the morning for only one week. Patients were then asked to answer a questionnaire about joint pain symptoms at one week, one month and two months after the beginning of prednisolone use. Joint pain symptoms improved in 67% of patients immediately after prednisolone use, with 63% still reporting analgesic effect at one month, and 52% at two months after beginning internal use of prednisolone. At one week, one month and two months after the use of prednisolone, 30%, 30% and 26% of patients reported improved daily life, respectively. Our results suggest that prednisolone could substitute non-steroidal antiinflammatory drugs, acetoaminophen or cyclooxygenase-2 inhibitors in patients with AI-induced arthralgia.

元の言語英語
ページ(範囲)2331-2336
ページ数6
ジャーナルAnticancer research
32
発行部数6
出版物ステータス出版済み - 6 1 2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

フィンガープリント Short-term and low-dose prednisolone administration reduces aromatase inhibitor-induced arthralgia in patients with breast cancer' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Kubo, M., Onishi, H., Kuroki, S., Okido, M., Shimada, K., Yokohata, K., Umeda, S., Ogawa, T., Tanaka, M., & Katano, M. (2012). Short-term and low-dose prednisolone administration reduces aromatase inhibitor-induced arthralgia in patients with breast cancer. Anticancer research, 32(6), 2331-2336.