Sick sinus syndrome observed in a patient with cholinesterase deficiency

Shioto Yasuda, Mitsuhiro Fukata, Taku Yokoyama, Takeshi Arita, Keita Odashiro, Toru Maruyama, Yoichiro Hiramoto, Koichi Akashi

研究成果: Contribution to journalArticle


A 58-year-old woman complained of general fatigue and was diagnosed with sick sinus syndrome (SSS) by ambulatory electrocardiogram, which demonstrated sinus arrest at midnight and paroxysmal atrial fibrillation (AF) at nighttime. Since her plasma cholinesterase (ChE) activity had been persistently zero, she was diagnosed with ChE deficiency. She refused permanent pacemaker implantation, and treatment with positive chronotropic drugs is ongoing. A novel association of ChE deficiency with SSS is theoretically possible rather than coincident, considering that ChE plays a key role in cholinergic influences on the sinus node leading to sinus bradyarrhythmia and on the atria, causing vagally mediated AF.

ジャーナルInternal Medicine
出版物ステータス出版済み - 2019

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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