Signal transduction from bradykinin, angiotensin, adrenergic and muscarinic receptors to effector enzymes, including ADP-ribosyl cyclase

H. Higashida, S. Yokoyama, N. Hoshi, M. Hashii, A. Egorova, Z. G. Zhong, M. Noda, M. Shahidullah, M. Taketo, R. Knijnik, Y. Kimura, H. Takahashi, X. L. Chen, Y. Shin, J. S. Zhang

研究成果: Contribution to journalReview article査読

20 被引用数 (Scopus)

抄録

Muscarinic acetylcholine receptors in NG108-15 neuroblastoma x glioma cells, and β-adrenergic or angiotensin II receptors in cortical astrocytes and/or ventricular myocytes, utilize the direct signaling pathway to ADP-ribosyl cyclase within cell membranes to produce cyclic ADP-ribose (cADPR) from β-NAD+. This signal cascade is analogous to the previously established transduction pathways from bradykinin receptors to phospholipase Cβ and β-adrenoceptors to adenylyl cyclase via G proteins. Upon receptor stimulation, the newly-formed cADPR may coordinately function to upregulate the release of Ca2+ from the type II ryanodine receptors as well as to facilitate Ca2+ influx through voltage-dependent Ca2+ channels. cADPR interacts with FK506, an immunosuppressant, at FKBP12.6, FK506-binding-protein, and calcineurin, or ryanodine receptors. cADPR also functions through activating calcineurin released from A-kinase anchoring protein (AKAP79). Thus, some Gq/11-coupled receptors can control cADPR-dependent modulation in Ca2+ signaling.

本文言語英語
ページ(範囲)23-30
ページ数8
ジャーナルBiological chemistry
382
1
DOI
出版ステータス出版済み - 2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry

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