Signatures in the gut microbiota of Japanese infants who developed food allergies in early childhood

Masaru Tanaka, Yuki Korenori, Masakazu Washio, Takako Kobayashi, Rie Momoda, Chikako Kiyohara, Aki Kuroda, Yuka Saito, Kenji Sonomoto, Jiro Nakayama

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

抄録

Bacterial colonization in infancy is considered crucial for the development of the immune system. Recently, there has been a drastic increase in childhood allergies in Japan. Therefore, we conducted a prospective study with 56 infants on the relationship between gut microbiota in the first year of life and the development of allergies during the first 3 years. In the lactation period, organic acid producers such as Leuconostoc, Weissella and Veillonella tended to be underrepresented in subjects who developed food allergies (FA, n = 14) within the first two years. In the weaning period, children in the FA group were highly colonized by unclassified Enterobacteriaceae and two Clostridium species closely related to Clostridium paraputrificum and C. tertium, and the whole tree phylogenetic diversity index was significantly lower in the FA group. All of these differences in the weaning period were statistically significant, even after adjusting for potential confounding factors. A higher abundance of unclassified Enterobacteriaceae was also found in the other allergic group (n = 15), whereas the two Clostridium species were highly specific to the FA group. The mode of action of these Clostridium species in childhood food allergies remains unknown, warranting further investigation.

元の言語英語
ジャーナルFEMS microbiology ecology
93
発行部数8
DOI
出版物ステータス出版済み - 8 1 2017

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allergy
Food Hypersensitivity
Clostridium
food
weaning
Enterobacteriaceae
Weaning
Hypersensitivity
Weissella
Veillonella
Leuconostoc
lactation
immune system
diversity index
organic acid
Lactation
Immune System
Japan
colonization
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Ecology
  • Applied Microbiology and Biotechnology

これを引用

Signatures in the gut microbiota of Japanese infants who developed food allergies in early childhood. / Tanaka, Masaru; Korenori, Yuki; Washio, Masakazu; Kobayashi, Takako; Momoda, Rie; Kiyohara, Chikako; Kuroda, Aki; Saito, Yuka; Sonomoto, Kenji; Nakayama, Jiro.

:: FEMS microbiology ecology, 巻 93, 番号 8, 01.08.2017.

研究成果: ジャーナルへの寄稿記事

Tanaka, Masaru ; Korenori, Yuki ; Washio, Masakazu ; Kobayashi, Takako ; Momoda, Rie ; Kiyohara, Chikako ; Kuroda, Aki ; Saito, Yuka ; Sonomoto, Kenji ; Nakayama, Jiro. / Signatures in the gut microbiota of Japanese infants who developed food allergies in early childhood. :: FEMS microbiology ecology. 2017 ; 巻 93, 番号 8.
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