Significance of abnormalities in systems proximal and distal to the obstructed site of duodenal atresia

Fatima S. Alatas, Kouji Masumoto, Genshiro Esumi, Kouji Nagata, Tomoaki Taguchi

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

BACKGROUND:: Duodenal atresia (DA) is a well-known neonatal intestinal disease. Even after surgery, the proximal segment can continue to be severely dilated with hypoperistalsis, resulting in intestinal dysmotility problems in later life. No data have been published regarding the morphologic differences between the proximal and distal regions of obstructed sites of the intramural components in DA. METHODS:: Operative duodenal samples (N=12) from cases with DA (age 1-3 days) were used. Age-matched controls (N=2) were used. All of the specimens were immunohistochemically stained with antibodies to S-100 protein, α-smooth muscle actin, and c-kit protein. RESULTS:: At the proximal segments of the obstructed site in DA, the number of neuronal cells decreased in size and number. The circular musculature was moderately to severely hypertrophic. Unusual ectopic smooth muscle bundles were also identified. The innermost layer of the circular musculature was thinner. Interstitial cells of Cajal are decreased, even around the myenteric plexus. All of the staining in the distal segments in DA was similar to the control tissues. CONCLUSIONS:: Proximal and distal segments in DA differ in the neural cells, musculature, and distributions of the interstitial cells of Cajal. Based on the present study, these morphologic changes may contribute to the onset of postoperative duodenal dysmotility.

元の言語英語
ページ(範囲)242-247
ページ数6
ジャーナルJournal of pediatric gastroenterology and nutrition
54
発行部数2
DOI
出版物ステータス出版済み - 2 1 2012

Fingerprint

Interstitial Cells of Cajal
Smooth Muscle
Infant, Newborn, Diseases
Proto-Oncogene Proteins c-kit
Myenteric Plexus
Intestinal Diseases
S100 Proteins
Actins
Cell Count
Familial duodenal atresia
Staining and Labeling
Antibodies

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

これを引用

Significance of abnormalities in systems proximal and distal to the obstructed site of duodenal atresia. / Alatas, Fatima S.; Masumoto, Kouji; Esumi, Genshiro; Nagata, Kouji; Taguchi, Tomoaki.

:: Journal of pediatric gastroenterology and nutrition, 巻 54, 番号 2, 01.02.2012, p. 242-247.

研究成果: ジャーナルへの寄稿記事

Alatas, Fatima S. ; Masumoto, Kouji ; Esumi, Genshiro ; Nagata, Kouji ; Taguchi, Tomoaki. / Significance of abnormalities in systems proximal and distal to the obstructed site of duodenal atresia. :: Journal of pediatric gastroenterology and nutrition. 2012 ; 巻 54, 番号 2. pp. 242-247.
@article{91eb7b9fe7044453916c17c9f9e25c79,
title = "Significance of abnormalities in systems proximal and distal to the obstructed site of duodenal atresia",
abstract = "BACKGROUND:: Duodenal atresia (DA) is a well-known neonatal intestinal disease. Even after surgery, the proximal segment can continue to be severely dilated with hypoperistalsis, resulting in intestinal dysmotility problems in later life. No data have been published regarding the morphologic differences between the proximal and distal regions of obstructed sites of the intramural components in DA. METHODS:: Operative duodenal samples (N=12) from cases with DA (age 1-3 days) were used. Age-matched controls (N=2) were used. All of the specimens were immunohistochemically stained with antibodies to S-100 protein, α-smooth muscle actin, and c-kit protein. RESULTS:: At the proximal segments of the obstructed site in DA, the number of neuronal cells decreased in size and number. The circular musculature was moderately to severely hypertrophic. Unusual ectopic smooth muscle bundles were also identified. The innermost layer of the circular musculature was thinner. Interstitial cells of Cajal are decreased, even around the myenteric plexus. All of the staining in the distal segments in DA was similar to the control tissues. CONCLUSIONS:: Proximal and distal segments in DA differ in the neural cells, musculature, and distributions of the interstitial cells of Cajal. Based on the present study, these morphologic changes may contribute to the onset of postoperative duodenal dysmotility.",
author = "Alatas, {Fatima S.} and Kouji Masumoto and Genshiro Esumi and Kouji Nagata and Tomoaki Taguchi",
year = "2012",
month = "2",
day = "1",
doi = "10.1097/MPG.0b013e31822d0d57",
language = "English",
volume = "54",
pages = "242--247",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Significance of abnormalities in systems proximal and distal to the obstructed site of duodenal atresia

AU - Alatas, Fatima S.

AU - Masumoto, Kouji

AU - Esumi, Genshiro

AU - Nagata, Kouji

AU - Taguchi, Tomoaki

PY - 2012/2/1

Y1 - 2012/2/1

N2 - BACKGROUND:: Duodenal atresia (DA) is a well-known neonatal intestinal disease. Even after surgery, the proximal segment can continue to be severely dilated with hypoperistalsis, resulting in intestinal dysmotility problems in later life. No data have been published regarding the morphologic differences between the proximal and distal regions of obstructed sites of the intramural components in DA. METHODS:: Operative duodenal samples (N=12) from cases with DA (age 1-3 days) were used. Age-matched controls (N=2) were used. All of the specimens were immunohistochemically stained with antibodies to S-100 protein, α-smooth muscle actin, and c-kit protein. RESULTS:: At the proximal segments of the obstructed site in DA, the number of neuronal cells decreased in size and number. The circular musculature was moderately to severely hypertrophic. Unusual ectopic smooth muscle bundles were also identified. The innermost layer of the circular musculature was thinner. Interstitial cells of Cajal are decreased, even around the myenteric plexus. All of the staining in the distal segments in DA was similar to the control tissues. CONCLUSIONS:: Proximal and distal segments in DA differ in the neural cells, musculature, and distributions of the interstitial cells of Cajal. Based on the present study, these morphologic changes may contribute to the onset of postoperative duodenal dysmotility.

AB - BACKGROUND:: Duodenal atresia (DA) is a well-known neonatal intestinal disease. Even after surgery, the proximal segment can continue to be severely dilated with hypoperistalsis, resulting in intestinal dysmotility problems in later life. No data have been published regarding the morphologic differences between the proximal and distal regions of obstructed sites of the intramural components in DA. METHODS:: Operative duodenal samples (N=12) from cases with DA (age 1-3 days) were used. Age-matched controls (N=2) were used. All of the specimens were immunohistochemically stained with antibodies to S-100 protein, α-smooth muscle actin, and c-kit protein. RESULTS:: At the proximal segments of the obstructed site in DA, the number of neuronal cells decreased in size and number. The circular musculature was moderately to severely hypertrophic. Unusual ectopic smooth muscle bundles were also identified. The innermost layer of the circular musculature was thinner. Interstitial cells of Cajal are decreased, even around the myenteric plexus. All of the staining in the distal segments in DA was similar to the control tissues. CONCLUSIONS:: Proximal and distal segments in DA differ in the neural cells, musculature, and distributions of the interstitial cells of Cajal. Based on the present study, these morphologic changes may contribute to the onset of postoperative duodenal dysmotility.

UR - http://www.scopus.com/inward/record.url?scp=84856305833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856305833&partnerID=8YFLogxK

U2 - 10.1097/MPG.0b013e31822d0d57

DO - 10.1097/MPG.0b013e31822d0d57

M3 - Article

C2 - 21760545

AN - SCOPUS:84856305833

VL - 54

SP - 242

EP - 247

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 2

ER -