Significance of immunohistochemical over-expression of CD44v6 as an indicator of malignant potential in esophageal squamous cell carcinoma

T. Nozoe, S. Kohnoe, T. Ezaki, A. Kabashima, Y. Maehara

研究成果: Contribution to journalArticle査読

19 被引用数 (Scopus)

抄録

Purpose: The aim of the current study was to find out a clinicopathologic significance of CD44v6 over-expression in esophageal squamous cell carcinoma (ESCC), which has not been elucidated fully. Methods: Immunohistochemical expression of CD44v6 was examined for 81 ESCCs. Correlation of CD44 over-expression with the clinicopathologic features were investigated. Results: Thirty-eight ESCCs (46.9%) had over-expression of CD44v6. The proportions of the incidence of lymph node metastasis (P = 0.039), lymphatic permeation (P = 0.003), and blood vessel invasion (P = 0.037) in ESCCs with over-expression of CD44v6 were significantly higher than those in ESCCs without over-expression of CD44v6. The stage of the tumor in ESCCs with over-expression of CD44v6 was significantly more advanced (P = 0.045). Survival rates of patients with ESCC with over-expression of CD44v6 were significantly worse (P = 0.0005). Moreover, CD44v6 over-expression (P = 0.048) as well as blood vessel invasion (P = 0.014) and stage of the tumor (P = 0.010) were factors independently associated withthe unfavorable prognosis of the patients with ESCC. Conclusions: Over-expression of CD44v6 can be an indicator of the malignant potential of ESCC.

本文言語英語
ページ(範囲)334-338
ページ数5
ジャーナルJournal of Cancer Research and Clinical Oncology
130
6
DOI
出版ステータス出版済み - 6 2004

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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