Significance of INHBA expression in human colorectal cancer

Miho Okano, Hirofumi Yamamoto, Hisataka Ohkuma, Yoshihiro Kano, Hirotoshi Kim, Shimpei Nishikawa, Masamitsu Konno, Koichi Kawamoto, Naotsugu Haraguchi, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Takehiko Yokobori, Koshi Mimori, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori, Hideshi Ishii

研究成果: Contribution to journalArticle査読

43 被引用数 (Scopus)

抄録

Inhibin β A (INHBA) is a member of the transforming growth factor β (TGF-β) superfamily. INHBA expression is associated with several types of human cancers; however, its significance in colorectal cancer (CRC) is not fully understood. INHBA expression was studied in 126 primary CRC samples and 4 CRC cell lines. Cell growth was assessed after inhibition of INHBA e xpression o r a fter e xogenous overexpression of INHBA in CRC tissues. INHBA expression was significantly higher in CRC tissues when compared to that in the corresponding normal tissues (P<0.001). Patients in the high expression group showed a poorer overall survival rate when compared to those in the low expression group (P<0.001); the present study did not evaluate for an independent prognostic factor but showed the significance of lymph node metastasis as an independent prognostic factor. The present study suggests that INHBA is useful as a predictive marker for prognosis in CRC patients.

本文言語英語
ページ(範囲)2903-2908
ページ数6
ジャーナルOncology reports
30
6
DOI
出版ステータス出版済み - 12 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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