Significance of Spread Through Air Spaces in Resected Lung Adenocarcinomas With Lymph Node Metastasis

Gouji Toyokawa, Yuichi Yamada, Tetsuzo Tagawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Fumihiko Hirai, Yoshinao Oda, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抄録

To clarify the prognostic impact of spread through air spaces (STAS) on survival in completely resected adenocarcinomas with lymph node metastasis, we observed STAS in 45 (73.0%) of 63 patients. Those with STAS had a significantly shorter recurrence-free survival (RFS) than those without STAS (P =.04). Positivity for STAS was an independent prognostic parameter for RFS. Background: Spread through air spaces (STAS) is a recently recognized invasive pattern of lung cancer defined by the World Health Organization as micropapillary clusters, solid nests, or single cells spreading within air spaces beyond the edge of the main tumor. Although STAS has been shown to be a significant prognosticator for the postoperative survival in early-stage lung cancer treated with limited resection, its prognostic impact on the survival in completely resected adenocarcinomas with lymph node metastasis remains unclear. Patients and Methods: STAS was assessed in a total of 63 adenocarcinomas with lymph node metastasis in patients who underwent complete resection. STAS was defined as tumor cells within air spaces in the lung parenchyma beyond the edge of the main tumor. We evaluated the association between STAS and the clinicopathologic characteristics and the postoperative survival. Results: Among 63 patients, 31 (49.2%) and 32 (50.8%) had disease that was pathologically positive for N1 and N2, respectively. STAS was observed in 45 patients (73.0%) and was not significantly associated with any clinicopathologic characteristics. Patients with the STAS had significantly shorter recurrence-free survival (RFS) but not overall survival than those without STAS (P =.04 and P =.35, respectively). The 5-year RFS in patients with and without STAS was 25.1% and 56.7%, respectively. According to a multivariate analysis, positivity for STAS remained an independent prognostic parameter for RFS (hazard ratio = 3.09; 95% confidence interval, 1.47-7.16; P <.01). Conclusion: STAS was predictive of a poor RFS in completely resected adenocarcinomas with lymph node metastasis.

元の言語英語
ページ(範囲)395-400.e1
ジャーナルClinical Lung Cancer
19
発行部数5
DOI
出版物ステータス出版済み - 9 1 2018

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Lymph Nodes
Air
Neoplasm Metastasis
Survival
Recurrence
Adenocarcinoma
Adenocarcinoma of lung
Lung Neoplasms
Neoplasms
Multivariate Analysis
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

これを引用

Significance of Spread Through Air Spaces in Resected Lung Adenocarcinomas With Lymph Node Metastasis. / Toyokawa, Gouji; Yamada, Yuichi; Tagawa, Tetsuzo; Kinoshita, Fumihiko; Kozuma, Yuka; Matsubara, Taichi; Haratake, Naoki; Takamori, Shinkichi; Akamine, Takaki; Hirai, Fumihiko; Oda, Yoshinao; Maehara, Yoshihiko.

:: Clinical Lung Cancer, 巻 19, 番号 5, 01.09.2018, p. 395-400.e1.

研究成果: ジャーナルへの寄稿記事

Toyokawa, G, Yamada, Y, Tagawa, T, Kinoshita, F, Kozuma, Y, Matsubara, T, Haratake, N, Takamori, S, Akamine, T, Hirai, F, Oda, Y & Maehara, Y 2018, 'Significance of Spread Through Air Spaces in Resected Lung Adenocarcinomas With Lymph Node Metastasis', Clinical Lung Cancer, 巻. 19, 番号 5, pp. 395-400.e1. https://doi.org/10.1016/j.cllc.2018.04.002
Toyokawa, Gouji ; Yamada, Yuichi ; Tagawa, Tetsuzo ; Kinoshita, Fumihiko ; Kozuma, Yuka ; Matsubara, Taichi ; Haratake, Naoki ; Takamori, Shinkichi ; Akamine, Takaki ; Hirai, Fumihiko ; Oda, Yoshinao ; Maehara, Yoshihiko. / Significance of Spread Through Air Spaces in Resected Lung Adenocarcinomas With Lymph Node Metastasis. :: Clinical Lung Cancer. 2018 ; 巻 19, 番号 5. pp. 395-400.e1.
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title = "Significance of Spread Through Air Spaces in Resected Lung Adenocarcinomas With Lymph Node Metastasis",
abstract = "To clarify the prognostic impact of spread through air spaces (STAS) on survival in completely resected adenocarcinomas with lymph node metastasis, we observed STAS in 45 (73.0{\%}) of 63 patients. Those with STAS had a significantly shorter recurrence-free survival (RFS) than those without STAS (P =.04). Positivity for STAS was an independent prognostic parameter for RFS. Background: Spread through air spaces (STAS) is a recently recognized invasive pattern of lung cancer defined by the World Health Organization as micropapillary clusters, solid nests, or single cells spreading within air spaces beyond the edge of the main tumor. Although STAS has been shown to be a significant prognosticator for the postoperative survival in early-stage lung cancer treated with limited resection, its prognostic impact on the survival in completely resected adenocarcinomas with lymph node metastasis remains unclear. Patients and Methods: STAS was assessed in a total of 63 adenocarcinomas with lymph node metastasis in patients who underwent complete resection. STAS was defined as tumor cells within air spaces in the lung parenchyma beyond the edge of the main tumor. We evaluated the association between STAS and the clinicopathologic characteristics and the postoperative survival. Results: Among 63 patients, 31 (49.2{\%}) and 32 (50.8{\%}) had disease that was pathologically positive for N1 and N2, respectively. STAS was observed in 45 patients (73.0{\%}) and was not significantly associated with any clinicopathologic characteristics. Patients with the STAS had significantly shorter recurrence-free survival (RFS) but not overall survival than those without STAS (P =.04 and P =.35, respectively). The 5-year RFS in patients with and without STAS was 25.1{\%} and 56.7{\%}, respectively. According to a multivariate analysis, positivity for STAS remained an independent prognostic parameter for RFS (hazard ratio = 3.09; 95{\%} confidence interval, 1.47-7.16; P <.01). Conclusion: STAS was predictive of a poor RFS in completely resected adenocarcinomas with lymph node metastasis.",
author = "Gouji Toyokawa and Yuichi Yamada and Tetsuzo Tagawa and Fumihiko Kinoshita and Yuka Kozuma and Taichi Matsubara and Naoki Haratake and Shinkichi Takamori and Takaki Akamine and Fumihiko Hirai and Yoshinao Oda and Yoshihiko Maehara",
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T1 - Significance of Spread Through Air Spaces in Resected Lung Adenocarcinomas With Lymph Node Metastasis

AU - Toyokawa, Gouji

AU - Yamada, Yuichi

AU - Tagawa, Tetsuzo

AU - Kinoshita, Fumihiko

AU - Kozuma, Yuka

AU - Matsubara, Taichi

AU - Haratake, Naoki

AU - Takamori, Shinkichi

AU - Akamine, Takaki

AU - Hirai, Fumihiko

AU - Oda, Yoshinao

AU - Maehara, Yoshihiko

PY - 2018/9/1

Y1 - 2018/9/1

N2 - To clarify the prognostic impact of spread through air spaces (STAS) on survival in completely resected adenocarcinomas with lymph node metastasis, we observed STAS in 45 (73.0%) of 63 patients. Those with STAS had a significantly shorter recurrence-free survival (RFS) than those without STAS (P =.04). Positivity for STAS was an independent prognostic parameter for RFS. Background: Spread through air spaces (STAS) is a recently recognized invasive pattern of lung cancer defined by the World Health Organization as micropapillary clusters, solid nests, or single cells spreading within air spaces beyond the edge of the main tumor. Although STAS has been shown to be a significant prognosticator for the postoperative survival in early-stage lung cancer treated with limited resection, its prognostic impact on the survival in completely resected adenocarcinomas with lymph node metastasis remains unclear. Patients and Methods: STAS was assessed in a total of 63 adenocarcinomas with lymph node metastasis in patients who underwent complete resection. STAS was defined as tumor cells within air spaces in the lung parenchyma beyond the edge of the main tumor. We evaluated the association between STAS and the clinicopathologic characteristics and the postoperative survival. Results: Among 63 patients, 31 (49.2%) and 32 (50.8%) had disease that was pathologically positive for N1 and N2, respectively. STAS was observed in 45 patients (73.0%) and was not significantly associated with any clinicopathologic characteristics. Patients with the STAS had significantly shorter recurrence-free survival (RFS) but not overall survival than those without STAS (P =.04 and P =.35, respectively). The 5-year RFS in patients with and without STAS was 25.1% and 56.7%, respectively. According to a multivariate analysis, positivity for STAS remained an independent prognostic parameter for RFS (hazard ratio = 3.09; 95% confidence interval, 1.47-7.16; P <.01). Conclusion: STAS was predictive of a poor RFS in completely resected adenocarcinomas with lymph node metastasis.

AB - To clarify the prognostic impact of spread through air spaces (STAS) on survival in completely resected adenocarcinomas with lymph node metastasis, we observed STAS in 45 (73.0%) of 63 patients. Those with STAS had a significantly shorter recurrence-free survival (RFS) than those without STAS (P =.04). Positivity for STAS was an independent prognostic parameter for RFS. Background: Spread through air spaces (STAS) is a recently recognized invasive pattern of lung cancer defined by the World Health Organization as micropapillary clusters, solid nests, or single cells spreading within air spaces beyond the edge of the main tumor. Although STAS has been shown to be a significant prognosticator for the postoperative survival in early-stage lung cancer treated with limited resection, its prognostic impact on the survival in completely resected adenocarcinomas with lymph node metastasis remains unclear. Patients and Methods: STAS was assessed in a total of 63 adenocarcinomas with lymph node metastasis in patients who underwent complete resection. STAS was defined as tumor cells within air spaces in the lung parenchyma beyond the edge of the main tumor. We evaluated the association between STAS and the clinicopathologic characteristics and the postoperative survival. Results: Among 63 patients, 31 (49.2%) and 32 (50.8%) had disease that was pathologically positive for N1 and N2, respectively. STAS was observed in 45 patients (73.0%) and was not significantly associated with any clinicopathologic characteristics. Patients with the STAS had significantly shorter recurrence-free survival (RFS) but not overall survival than those without STAS (P =.04 and P =.35, respectively). The 5-year RFS in patients with and without STAS was 25.1% and 56.7%, respectively. According to a multivariate analysis, positivity for STAS remained an independent prognostic parameter for RFS (hazard ratio = 3.09; 95% confidence interval, 1.47-7.16; P <.01). Conclusion: STAS was predictive of a poor RFS in completely resected adenocarcinomas with lymph node metastasis.

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