新規抗てんかん薬血中濃度測定の内製化による効果

Kimitaka Suetsugu, Nanae Yamamoto, Tomohiro Shigematsu, Daisuke Kobayashi, Yuichi Tsuchiya, Yurie Nakayama, Toshikazu Tsuji, Hiroyuki Watanabe, Akiko Kanaya, Satohiro Masuda, Nobuaki Egashira

研究成果: Contribution to journalArticle

抜粋

For many of the novel antiepileptics, immunoassays, used for routine therapeutic drug monitoring (TDM), cannot be used. We could monitor eight novel antiepileptics using an LC/MS method since July 2017. The purpose of this study was to evaluate the significant changes associated with the transition from outsourcing to in-hospital monitoring of novel antiepileptics. The number of measurements of novel antiepileptics was significantly increased during the first (p<0.01) and second (p<0.001) years of in-hospital monitoring as compared to that one year prior to in-hospital monitoring which was outsourced. The proportion of measurements of novel antiepileptics to all antiepileptics was 19.7%, 31.1%, and 38.4% during outsourcing, and first, and second years of in-hospital monitoring, respectively. The measurement cost was significantly reduced during the first (p<0.001) and second (p<0.001) years of in-hospital monitoring as compared to that during outsourcing. In addition, the revenue from TDM of antiepileptic drugs was significantly increased during the first (p<0.05) and second (p<0.01) years of in-hospital monitoring as compared with that during outsourcing. In conclusion, the switch from outsourcing to in-hospital monitoring led to an increase in the number of orders, a reduction in the measurement-related expenses of novel antiepileptics, and an increase in the revenue from TDM of antiepileptic drugs, which could promote the proper use of novel antiepileptics through TDM.

寄稿の翻訳されたタイトルSignificant changes associated with the transition from outsourcing to in-hospital therapeutic drug monitoring of novel antiepileptics
元の言語Japanese
ページ(範囲)1035-1040
ページ数6
ジャーナルYakugaku Zasshi
140
発行部数8
DOI
出版物ステータス出版済み - 2020

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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    Suetsugu, K., Yamamoto, N., Shigematsu, T., Kobayashi, D., Tsuchiya, Y., Nakayama, Y., Tsuji, T., Watanabe, H., Kanaya, A., Masuda, S., & Egashira, N. (2020). 新規抗てんかん薬血中濃度測定の内製化による効果. Yakugaku Zasshi, 140(8), 1035-1040. https://doi.org/10.1248/yakushi.20-00001