Significant induction of a 54-kDa protein in rat liver with homologous alignment to mouse selenium binding protein by a coplanar polychlorinated biphenyl, 3,4,5,3',4'pentachlorobiphenyl and 3-methylcholanthrene

Yuji Ishii, Megumu Hatsumura, Takumi Ishida, Noritaka Ariyoshi, Kazuta Oguri

研究成果: ジャーナルへの寄稿記事

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A 54-kDa protein in rat liver cytosol was significantly induced by treatment with 3,4,5,3',4' -pentachlorobiphenyl (25 mg/kg, single i.p.) and 3-methylcholanthrene (20 mg/kg, once a day for 3 days, i.p.). The protein exhibited pI of 6.8 on two-dimensional gel electrophoresis. The amino acid sequences of peptide fragments from the protein digested in situ were highly similar to a selenium binding protein in mice and to the isoform acetaminophen binding protein in mice. The present result clearly demonstrates that a coplanar polychlorinated biphenyl and 3-methylcholanthrene are responsible for induction of selenium binding protein homologues. The physiological role of the mouse proteins, however, is not yet elucidated.

元の言語英語
ページ(範囲)1-9
ページ数9
ジャーナルToxicology Letters
87
発行部数1
DOI
出版物ステータス出版済み - 9 1996

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All Science Journal Classification (ASJC) codes

  • Toxicology

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