Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl

Yuji Ishii, Harutoshi Kato, Megumu Hatsumura, Takumi Ishida, Noritaka Ariyoshi, Kazuta Oguri

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

A toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl (PenCB), significantly suppresses the expression of liver aldolase B in rats. Hepatic aldolase activity in PenCB-treated rats was significantly reduced to about 50% of that in free- and pair-fed control groups. The reduced aldolase activity following PenCB-treatment was due to the marked suppression of the expression of aldolase B shown by immunoblot analysis after SDS-polyacrylamide gel electrophoresis and two-dimensional gel electrophoresis. The suppression of rat liver aldolase B could be a key biochemical lesion caused by PenCB.

本文言語英語
ページ(範囲)193-199
ページ数7
ジャーナルToxicology
116
1-3
DOI
出版ステータス出版済み - 1 15 1997

All Science Journal Classification (ASJC) codes

  • Toxicology

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