Similar metabolic responses to calorie restriction in lean and obese Zucker rats

Takuya Chiba, Toshimitsu Komatsu, Masahiko Nakayama, Toshiyuki Adachi, Yukari Tamashiro, Hiroko Hayashi, Haruyoshi Yamaza, Yoshikazu Higami, Isao Shimokawa

研究成果: ジャーナルへの寄稿記事

22 引用 (Scopus)

抄録

Calorie restriction (CR), which is thought to be largely dependent on the neuroendocrine system modulated by insulin/insulin-like growth factor-I (IGF-I) and leptin signaling, decreases morbidity and increases lifespan in many organisms. To elucidate whether insulin and leptin sensitivities are indispensable in the metabolic adaptation to CR, we investigated the effects of CR on obese Zucker (fa/fa) rats and lean control (+/+) rats. CR did not fully improve insulin resistance in (fa/fa) rats. Nonetheless, CR induced neuropeptide Y (NPY) expression in the hypothalamic arcuate nucleus and metabolism related gene expression changes in the liver in (fa/fa) rats and (+/+) rats. Up-regulation of NPY augmented plasma corticosterone levels and suppressed pituitary growth hormone (GH) expression, thereby modulating adipocytokine production to induce tissue-specific insulin sensitivity. Thus, central NPY activation via peripheral signaling might play a crucial role in the effects of CR, even in insulin resistant and leptin receptor deficient conditions.

元の言語英語
ページ(範囲)17-25
ページ数9
ジャーナルMolecular and Cellular Endocrinology
309
発行部数1-2
DOI
出版物ステータス出版済み - 10 15 2009

Fingerprint

Zucker Rats
Rats
Insulin
Neuropeptide Y
Insulin Resistance
Leptin
Rat control
Leptin Receptors
Arcuate Nucleus of Hypothalamus
Neurosecretory Systems
Adipokines
Insulin Receptor
Corticosterone
Insulin-Like Growth Factor I
Metabolism
Gene expression
Liver
Growth Hormone
Up-Regulation
Chemical activation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

これを引用

Chiba, T., Komatsu, T., Nakayama, M., Adachi, T., Tamashiro, Y., Hayashi, H., ... Shimokawa, I. (2009). Similar metabolic responses to calorie restriction in lean and obese Zucker rats. Molecular and Cellular Endocrinology, 309(1-2), 17-25. https://doi.org/10.1016/j.mce.2009.05.001

Similar metabolic responses to calorie restriction in lean and obese Zucker rats. / Chiba, Takuya; Komatsu, Toshimitsu; Nakayama, Masahiko; Adachi, Toshiyuki; Tamashiro, Yukari; Hayashi, Hiroko; Yamaza, Haruyoshi; Higami, Yoshikazu; Shimokawa, Isao.

:: Molecular and Cellular Endocrinology, 巻 309, 番号 1-2, 15.10.2009, p. 17-25.

研究成果: ジャーナルへの寄稿記事

Chiba, T, Komatsu, T, Nakayama, M, Adachi, T, Tamashiro, Y, Hayashi, H, Yamaza, H, Higami, Y & Shimokawa, I 2009, 'Similar metabolic responses to calorie restriction in lean and obese Zucker rats', Molecular and Cellular Endocrinology, 巻. 309, 番号 1-2, pp. 17-25. https://doi.org/10.1016/j.mce.2009.05.001
Chiba T, Komatsu T, Nakayama M, Adachi T, Tamashiro Y, Hayashi H その他. Similar metabolic responses to calorie restriction in lean and obese Zucker rats. Molecular and Cellular Endocrinology. 2009 10 15;309(1-2):17-25. https://doi.org/10.1016/j.mce.2009.05.001
Chiba, Takuya ; Komatsu, Toshimitsu ; Nakayama, Masahiko ; Adachi, Toshiyuki ; Tamashiro, Yukari ; Hayashi, Hiroko ; Yamaza, Haruyoshi ; Higami, Yoshikazu ; Shimokawa, Isao. / Similar metabolic responses to calorie restriction in lean and obese Zucker rats. :: Molecular and Cellular Endocrinology. 2009 ; 巻 309, 番号 1-2. pp. 17-25.
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AU - Yamaza, Haruyoshi

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