複雑な計算スキームを必要とする多階層生体機能モデルのシミュレーションシステム

天野 晃, プンザラン フロレンシオ ラスティ, 嶋吉 隆夫, 國枝 義敏

研究成果: Contribution to journalArticle査読

抄録

Many biological findings are continuously reported in the life science area. Most of them are reports on the correlations between some proteins, or correlations between some proteins and macroscopic phenomena such as whole body hemodynamics. In order to understand the underlying mechanisms of the biological systems, simulation and analysis of multiscale biological function models are considered useful. Since the complex calculation schemes are necessary to calculate these models efficiently, it is useful to represent both the biological function models and the calculation schemes in descriptive languages which are readable by the computer programs. In this report, we introduce our simulation system which generates simulation programs from biological function models and calculation schemes both described by description languages. Using our system, we were able to generate simulation programs for a hemodynamic simulation model coupling a ventricular myocyte model and a whole body circulation model, a simulation model that evaluates the changes in action potential of a ventricular myocyte model after drug administration, and a program that calculates the changes in action potential of ventricular myocytes by changing specific parameters.
寄稿の翻訳タイトルSimulation System for Multiscale Biological Function Models that Require Complex Calculation Scheme
本文言語日本語
ページ(範囲)115-122
ページ数8
ジャーナルBME = Bio medical engineering / henshu, Nihon ME Gakkai
53
3
DOI
出版ステータス出版済み - 2015

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