Simultaneous separation, metering, and dilution of plasma from human whole blood in a microfluidic system

Tomoya Tachi, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba

研究成果: Contribution to journalArticle査読

67 被引用数 (Scopus)

抄録

In about a 3 min period, we have simultaneously separated plasma from human whole blood and metered and diluted the plasma using a microchip with an interchannel microstructure. The plasma separation was based on both cross-flow filtration and sedimentation of red blood cells in the microchannels. Metering and diluting operations of the plasma were based on volume control of liquid in the microchannels by syringe pumps. On this microchip, we produced plasma diluted by a factor of 6 from whole blood containing theophylline and we observed very little hemolysis. It is possible to separate plasma from one or just several drops of whole blood by using this microchip.

本文言語英語
ページ(範囲)3194-3198
ページ数5
ジャーナルAnalytical Chemistry
81
8
DOI
出版ステータス出版済み - 4 15 2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分析化学

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