Single CX3CL1-Ig DNA administration enhances T cell priming in vivo

Mutsunori Iga, Alexandre Boissonnas, Brice Mahé, Olivia Bonduelle, Christophe Combadière, Behazine Combadière

研究成果: ジャーナルへの寄稿学術誌査読

9 被引用数 (Scopus)

抄録

Upon antigenic stimulation, establishment of adaptive immune responses that determines vaccine efficacy is dependent on efficient T cell priming. Here, single CX3CL1-Ig DNA administration, a unique ligand of CX3CR1, together with viral or tumor antigens induced a strong in vivo antigen-specific T cell proliferation and effector function that was enough efficient to protect against a tumor challenge. We also showed that early expression of CX3CL1-Ig and antigens in muscle and lymphoid organs induces an increased in vivo migration of myeloid CD14+CD11c+ DC but not lymphoid CD8α+CD11c+ DC at these sites. Thus, by effectively directing DC toward lymphoid organs to encounter T cells, CX3CL1-Ig become a new candidate that augments T cell priming and increases efficiency of vaccination.

本文言語英語
ページ(範囲)4554-4563
ページ数10
ジャーナルVaccine
25
23
DOI
出版ステータス出版済み - 6月 6 2007

!!!All Science Journal Classification (ASJC) codes

  • 分子医療
  • 免疫学および微生物学(全般)
  • 獣医学(全般)
  • 公衆衛生学、環境および労働衛生
  • 感染症

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