Single neuron activity in the rat lateral hypothalamus during 2-deoxy-d-glucose induced and natural feeding behavior

Toshihiko Katafuchi, Yutaka Oomura, Hironobu Yoshimatsu

研究成果: Contribution to journalArticle査読

47 被引用数 (Scopus)

抄録

Single neuron activity in the lateral hypothalamic area (LHA) was recorded extracellularly in freely moving rats. Intra-third-cerebroventricular injection of 2-deoxy-d-glucose (2-DG) increased the activity in 38% of 69 neurons and decreased it in 19%. The remaining 43% of the neurons were not affected. Of the neurons excited, 50% showed definite inhibition of activity after long-lasting excitation. In 58% of the 69 neurons, the following changes in neuronal activity were observed during spontaneous feeding. Most of the tonic type neurons, which increased activity throughout the period of a meal, were excited by 2-DG, while the phasic type, which showed an abrupt increase in activity just before eating followed by a decrease, tended to be inhibited by 2-DG. Although injection of 2-DG induced feeding for a brief period in 61 cases (88%), the total food intake during 24 h was reduced significantly below normal. These findings indicate that 2-DG both excites and inhibits LHA neurons and induces facilitation followed by inhibition of feeding behavior.

本文言語英語
ページ(範囲)1-9
ページ数9
ジャーナルBrain Research
359
1-2
DOI
出版ステータス出版済み - 12 16 1985

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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