Sinulobatins A ~ D, new amphilectane-type diterpenoids from the Japanese soft coral Sinularia nanolobata

Koji Yamada, Tami Ujiie, Katsumi Yoshida, Tomofumi Miyamoto, Ryuichi Higuchi

研究成果: Contribution to journalArticle査読

20 被引用数 (Scopus)

抄録

Four new amphilectane-type diterpenoids, sinulobatins A (1), B (2), C (3) and D (4) were isolated from the Japanese soft coral Sinularia nanolobata. Their structures were determined based on spectroscopic evidence and single crystal X-ray analysis. The absolute stereochemistry of 1 was elucidated on the basis of its CD spectrum. These compounds exhibited cytotoxicity against L1210 cells and KB cells in vitro with IC50 values of 3.0-7.7 μg/mL.

本文言語英語
ページ(範囲)4569-4578
ページ数10
ジャーナルTetrahedron
53
13
DOI
出版ステータス出版済み - 3 31 1997

All Science Journal Classification (ASJC) codes

  • 生化学
  • 創薬
  • 有機化学

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