Sinulobatins A ~ D, new amphilectane-type diterpenoids from the Japanese soft coral Sinularia nanolobata

Koji Yamada, Tami Ujiie, Katsumi Yoshida, Tomofumi Miyamoto, Ryuichi Higuchi

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

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Four new amphilectane-type diterpenoids, sinulobatins A (1), B (2), C (3) and D (4) were isolated from the Japanese soft coral Sinularia nanolobata. Their structures were determined based on spectroscopic evidence and single crystal X-ray analysis. The absolute stereochemistry of 1 was elucidated on the basis of its CD spectrum. These compounds exhibited cytotoxicity against L1210 cells and KB cells in vitro with IC50 values of 3.0-7.7 μg/mL.

元の言語英語
ページ(範囲)4569-4578
ページ数10
ジャーナルTetrahedron
53
発行部数13
DOI
出版物ステータス出版済み - 3 31 1997

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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