Sister acts: Coordinating DNA replication and cohesion establishment

Rebecca Sherwood, Tatsuro S. Takahashi, Prasad V. Jallepalli

研究成果: Contribution to journalReview article査読

52 被引用数 (Scopus)

抄録

The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to generate cohesive linkages is restricted to S phase and depends on loading and establishment factors that are intimately connected to DNA replication. Here we review how cohesin is regulated by the replication machinery, as well as recent evidence that cohesin itself influences how chromosomes are replicated.

本文言語英語
ページ(範囲)2723-2731
ページ数9
ジャーナルGenes and Development
24
24
DOI
出版ステータス出版済み - 12 15 2010

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

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