Six-Month Aerobic Exercise Training Ameliorates Central Sleep Apnea in Patients With Chronic Heart Failure

Umpei Yamamoto, Masahiro Mohri, Kaoru Shimada, Hideki Origuchi, Kenji Miyata, Koji Ito, Kohtaro Abe, Hideo Yamamoto

研究成果: Contribution to journalArticle査読

43 被引用数 (Scopus)


Background: Sleep-disordered breathing (SDB) is common in patients with heart failure and carries an independent risk for poor long-term prognosis. We aimed to study the effects of supervised, aerobic exercise training for 6 months on SDB in patients with chronic heart failure. Methods and Results: We enrolled 18 patients having both systolic dysfunction (left ventricular ejection fraction <45%) and SDB (apnea-hypopnea index [AHI] >10). The exercise group comprised 10 patients who participated in our cardiac rehabilitation program for 6 months, and the remaining 8 patients served as control. AHI (median [interquartile range]) was unchanged in the control group patients at 6-month intervals (30.4 [19.9-36.3] versus 36.6 [8.6-39.4], NS). In contrast, AHI was significantly decreased in the exercise group from 24.9 [19.2-37.1] to 8.8 [5.3-10.1] (P < .01). In the exercise group, the numbers of central sleep apnea per night was significantly decreased (152 [124-244] versus 50 [24-67], P < .01) after exercise training, but those of obstructive apnea/hypopnea were unchanged (42 [7-94] versus 18 [7-54], NS). In addition, exercise training significantly increased peak oxygen consumption and decreased minute ventilation to carbon dioxide production slope (both P < .01). Conclusions: Six-month, aerobic exercise training increased exercise capacity and improved central sleep apnea in patients with chronic heart failure from systolic dysfunction.

ジャーナルJournal of Cardiac Failure
出版ステータス出版済み - 12 1 2007

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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