TY - JOUR
T1 - Skeletal muscle mass predicts the prognosis of patients with intrahepatic cholangiocarcinoma
AU - Yugawa, Kyohei
AU - Itoh, Shinji
AU - Kurihara, Takeshi
AU - Yoshiya, Shohei
AU - Mano, Yohei
AU - takeishi, kazuki
AU - Harada, Noboru
AU - Ikegami, Toru
AU - Soejima, Yuji
AU - Mori, Masaki
AU - Yoshizumi, Tomoharu
N1 - Funding Information:
This study was supported by the following three grants: JSPS KAKENHI , a Grant-in-Aid from the Ministry of Health, Labour and Welfare, Japan (Number JP-16K10576 ), JSPS KAKEN Grant (Number JP-15H05792 ) and the program for Basic and Clinical Research on Hepatitis from Japan Agency for Medical Research and Development , AMED. The funding sources had no role in the collection, analysis, or interpretation of the data, or in the decision to submit the article for publication.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/11
Y1 - 2019/11
N2 - Background: We studied the prognostic impact of sarcopenia after hepatic resection for intrahepatic cholangiocarcinoma (ICC). Methods: Sixty-one patients who underwent surgery for ICC during 2000–2017 were analyzed retrospectively. Psoas muscle areas were measured on CT scans at the third lumbar vertebra. Areas less than the sex-specific median were deemed low skeletal muscle masses (SMMs). Results: Low-SMM patients were significantly more often older (p = 0.002) than high-SMM patients, had lower serum albumin (p = 0.004), higher serum C-reactive protein (CRP) (p = 0.002), and higher carbohydrate antigen 19-9 (p < 0.001). Five-year overall survival rates were 72.5% and 17.6% and 5-year recurrence-free survival rates were 58.6% and 21.1%, respectively, in high- and low-SMM patients. Multivariable analysis revealed that low SMM predicted unfavorable prognoses. SMM was associated with immune nutritional status (e.g., prognostic nutritional index, Glasgow prognostic score, CRP/albumin ratio). Conclusion: Low SMM was related to worse surgical outcomes in patients with ICC following hepatic resection.
AB - Background: We studied the prognostic impact of sarcopenia after hepatic resection for intrahepatic cholangiocarcinoma (ICC). Methods: Sixty-one patients who underwent surgery for ICC during 2000–2017 were analyzed retrospectively. Psoas muscle areas were measured on CT scans at the third lumbar vertebra. Areas less than the sex-specific median were deemed low skeletal muscle masses (SMMs). Results: Low-SMM patients were significantly more often older (p = 0.002) than high-SMM patients, had lower serum albumin (p = 0.004), higher serum C-reactive protein (CRP) (p = 0.002), and higher carbohydrate antigen 19-9 (p < 0.001). Five-year overall survival rates were 72.5% and 17.6% and 5-year recurrence-free survival rates were 58.6% and 21.1%, respectively, in high- and low-SMM patients. Multivariable analysis revealed that low SMM predicted unfavorable prognoses. SMM was associated with immune nutritional status (e.g., prognostic nutritional index, Glasgow prognostic score, CRP/albumin ratio). Conclusion: Low SMM was related to worse surgical outcomes in patients with ICC following hepatic resection.
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U2 - 10.1016/j.amjsurg.2019.03.010
DO - 10.1016/j.amjsurg.2019.03.010
M3 - Article
C2 - 30902342
AN - SCOPUS:85063025182
SN - 0002-9610
VL - 218
SP - 952
EP - 958
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 5
ER -