Slowly progressive distal muscular atrophy of the bilateral upper limbs (O'Sullivan-McLeod syndrome) partially alleviated by intravenous immunoglobulin therapy

Yuji Kawano, Yuko Nagara, Hiroyuki Murai, Hitoshi Kikuchi, Yasumasa Ohyagi, Jun Ichi Kira

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

We report a case of O'Sullivan-McLeod syndrome in a 59-year-old man, who had experienced slowly progressive weakening of both hands since he was 20 years of age. Mild hyperIgEemia and eosinophilia were present. Nerve conduction studies revealed reduced F wave-evoked frequencies for the median and ulnar nerves. Intravenous immunoglobulin (IVIG) at a dose of 400 mg/kg/day was given for 5 days. After IVIG, the muscle weakness of the distal upper extremities improved together with increased F wave-evoked frequencies. These effects lasted for a few months. These observations suggest that immune-mediated neural damage partially contributes to O'Sullivan-McLeod syndrome.

本文言語英語
ページ(範囲)515-518
ページ数4
ジャーナルInternal Medicine
46
8
DOI
出版ステータス出版済み - 4 17 2007

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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