Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo

Akira Inoue, Markus G. Seidel, Wenshu Wu, Shintaro Kamizono, Adolfo A. Ferrando, Roderick T. Bronson, Hiromi Iwasaki, Koichi Akashi, Akira Morimoto, Johann K. Hitzler, Tamara I. Pestina, Carl W. Jackson, Ryuhei Tanaka, Miriam J. Chong, Peter J. McKinnon, Takeshi Inukai, Gerard C. Grosveld, A. Thomas Look

研究成果: Contribution to journalArticle査読

147 被引用数 (Scopus)

抄録

We show here that a zinc finger transcriptional repressor, Slug, which is aberrantly upregulated by the E2A-HLF oncoprotein in pro-B cell acute leukemia, functions as an antiapoptotic factor in normal hematopoietic progenitor cells. Slug-/- mice were much more radiosensitive than wild-type mice, dying earlier and showing accentuated decreases in peripheral blood cell counts, as well as abundant microhemorrhages and widely disseminated bacterial microabscesses throughout the body. Slug expression was detected in diverse subsets of hematopoietic progenitors, but not in more differentiated B and T lymphoid cells, and there was a significant increase in apoptotic (TUNEL-positive) bone marrow progenitor cells in irradiated Slug-/- mice compared to wild-type controls. These results implicate Slug in a novel survival pathway that protects hematopoietic progenitors from apoptosis after DNA damage.

本文言語英語
ページ(範囲)279-288
ページ数10
ジャーナルCancer Cell
2
4
DOI
出版ステータス出版済み - 10 2002
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 細胞生物学
  • 癌研究

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