Small heat-shock protein is expressed in meningiomas and in granulofilamentous inclusion bodies

N. Yokoyama, T. Iwaki, J. E. Goldman, J. Tateishi, M. Fukui

研究成果: ジャーナルへの寄稿学術誌査読

23 被引用数 (Scopus)

抄録

The cellular expression of estrogen receptor-related small heat-shock protein (HSP27) in meningiomas was investigated immunologically. A cytoplasmic distribution of HSP27 was demonstrated in surgical specimens of 22 of 26 cases with meningiomas and cultured meningioma cells derived from two individuals. By Western blotting, HSP27 was detected in every tissue homogenate of 17 cases studied. Thus, HSP27 appears to be constitutively expressed in most meningiomas. In anaplastic portions of one papillary meningioma, there were numerous granulofilamentous inclusion bodies [Goldman JE et al. (1980) Cancer 46:156-161]. The inclusion bodies were immunopositive for HSP27 despite the negativity of the tumor cytoplasms. Thus, HSP27 seems to participate in the formation of certain inclusion bodies in meningioma cells, like αB-crystallin which participates in the formation of Rosenthal fibers in astrocytes.

本文言語英語
ページ(範囲)248-255
ページ数8
ジャーナルActa neuropathologica
85
3
DOI
出版ステータス出版済み - 2月 1993

!!!All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 臨床神経学
  • 細胞および分子神経科学

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