SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients

J. P. McElroy, Noriko Isobe, P. A. Gourraud, S. J. Caillier, Takuya Matsushita, T. Kohriyama, K. Miyamoto, Y. Nakatsuji, T. Miki, S. L. Hauser, J. R. Oksenberg, Jun-Ichi Kira

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

抄録

Although several major histocompatibility complex (MHC)-wide single-nucleotide polymorphism (SNP) studies have been performed in populations of European descent, none have been performed in Asian populations. The objective of this study was to identify human leukocyte antigen (HLA) loci associated with multiple sclerosis (MS) in a Japanese population genotyped for 3534 MHC region SNPs. Using a logistic regression model, two SNPs (MHC Class III SNP rs422951 in the NOTCH4 gene and MHC Class II SNP rs3997849, susceptible alleles A and G, respectively) were independently associated with MS susceptibility (204 patients; 280 controls), two (MHC Class II SNP rs660895 and MHC Class I SNP rs2269704 in the NRM gene, susceptible alleles G and G, respectively) with aquaporin-4 (AQP4) MS susceptibility (149 patients; 280 controls) and a single SNP (MHC Class II SNP rs1694112, susceptible allele G) was significant when contrasting AQP4 against AQP4 patients. Haplotype analysis revealed a large susceptible association, likely DRB104 or a locus included in the DRB104 haplotype, with AQP4 MS, which excluded DRB115:01. This study is the largest study of the HLA's contribution to MS in Japanese individuals.

元の言語英語
ページ(範囲)523-530
ページ数8
ジャーナルGenes and Immunity
12
発行部数7
DOI
出版物ステータス出版済み - 10 20 2011

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HLA Antigens
Multiple Sclerosis
Single Nucleotide Polymorphism
Major Histocompatibility Complex
Aquaporin 4
Alleles
Haplotypes
Logistic Models
Population
Genes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics
  • Genetics(clinical)

これを引用

SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients. / McElroy, J. P.; Isobe, Noriko; Gourraud, P. A.; Caillier, S. J.; Matsushita, Takuya; Kohriyama, T.; Miyamoto, K.; Nakatsuji, Y.; Miki, T.; Hauser, S. L.; Oksenberg, J. R.; Kira, Jun-Ichi.

:: Genes and Immunity, 巻 12, 番号 7, 20.10.2011, p. 523-530.

研究成果: ジャーナルへの寄稿記事

McElroy, JP, Isobe, N, Gourraud, PA, Caillier, SJ, Matsushita, T, Kohriyama, T, Miyamoto, K, Nakatsuji, Y, Miki, T, Hauser, SL, Oksenberg, JR & Kira, J-I 2011, 'SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients', Genes and Immunity, 巻. 12, 番号 7, pp. 523-530. https://doi.org/10.1038/gene.2011.25
McElroy, J. P. ; Isobe, Noriko ; Gourraud, P. A. ; Caillier, S. J. ; Matsushita, Takuya ; Kohriyama, T. ; Miyamoto, K. ; Nakatsuji, Y. ; Miki, T. ; Hauser, S. L. ; Oksenberg, J. R. ; Kira, Jun-Ichi. / SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients. :: Genes and Immunity. 2011 ; 巻 12, 番号 7. pp. 523-530.
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