Social isolation stress exacerbates autoimmune disease in MRL/lpr mice

Yoichi Chida, Nobuyuki Sudo, Chiharu Kubo

研究成果: ジャーナルへの寄稿学術誌査読

37 被引用数 (Scopus)

抄録

The potential physiological mechanisms explaining an influence of psychosocial stress on autoimmune diseases remain undetermined. Exposure of chronic social isolation stress to MRL/lpr mice significantly enhanced the degree of proteinuria after 20 weeks of age and reduced the survival rate. The serum anti-dsDNA IgG2a levels were increased significantly by stress at 19 weeks of age, which was simultaneously accompanied by inhibition of the serum corticosterone elevation. Furthermore, stress caused increased IFN-γ production from anti-CD3-stimulated splenic mononuclear cells, whereas IL-4 and IL-10 production decreased. These results indicated that isolation stress exacerbated autoimmune disease in MRL/lpr mice, the possible mechanism for which might be related to stress-induced dysregulation of Th1/Th2 balance and inhibition of the blood corticosterone response to inflammatory stimuli.

本文言語英語
ページ(範囲)138-144
ページ数7
ジャーナルJournal of Neuroimmunology
158
1-2
DOI
出版ステータス出版済み - 1月 2005

!!!All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 神経学
  • 臨床神経学

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