Sodium fluxes and astroglial function

Alexei Verkhratsky, Mami Noda, Vladimir Parpura, Sergei Kirischuk

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

23 被引用数 (Scopus)

抄録

Astrocytes exhibit their excitability based on variations in cytosolic Ca2+ levels, which leads to variety of signalling events. Only recently, however, intracellular fluctuations of more abundant cation Na + are brought in the limelight of glial signalling. Indeed, astrocytes possess several plasmalemmal molecular entities that allow rapid transport of Na+ across the plasma membrane: (1) ionotropic receptors, (2) canonical transient receptor potential cation channels, (3) neurotransmitter transporters and (4) sodium-calcium exchanger. Concerted action of these molecules in controlling cytosolic Na+ may complement Ca2+ signalling to provide basis for complex bidirectional astrocyte-neurone communication at the tripartite synapse.

本文言語英語
ホスト出版物のタイトルSodium Calcium Exchange
ホスト出版物のサブタイトルA Growing Spectrum of Pathophysiological Implications: Proceedings of the 6th International Conference on Sodium Calcium Exchange
出版社Springer Science and Business Media, LLC
ページ295-305
ページ数11
ISBN(印刷版)9781461447559
DOI
出版ステータス出版済み - 2013

出版物シリーズ

名前Advances in Experimental Medicine and Biology
961
ISSN(印刷版)0065-2598

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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