TY - CHAP
T1 - Sol-gel-based bioceramics
T2 - From materials to medicine
AU - Arora, Bharti
AU - Park, Ji Hoon
AU - Choi, Eun Ha
AU - Attri, Pankaj
N1 - Publisher Copyright:
© 2018 Pan Stanford Publishing Pte. Ltd.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The progress of nanotechnology has opened the path for the development of new biomaterials. Recent developments have demonstrated that sol-gel bioceramics play an important role in the biomedical field due to their superior biological and mechanical properties. A bioactive hydroxyapatite (HA) is a common bioceramic that attaches to living tissues in vivo at body temperature. Sol-gel processes are now being used to produce bioactive coatings, powders, and substrates that can facilitate control over biological behavior of proteins and cells with broad clinical applications. It has been found that HA particles can down-regulate the expression of some cancerogenic genes in 432tumor cells. The nano-HA particles from the biodegradation of HA ceramics could penetrate the membranes of tumor cells. A rapid and economic sol-gel method has been designed to synthesize sodium silicate (Na2SiO3) into silica gel in large quantities. Sol-gel-based bioceramics have the potential to present unexpected excellent biological functions. Thus, the understanding and control of the interactions between bioceramics and biological entities may play one of the leading roles in the development of nanomedicine.
AB - The progress of nanotechnology has opened the path for the development of new biomaterials. Recent developments have demonstrated that sol-gel bioceramics play an important role in the biomedical field due to their superior biological and mechanical properties. A bioactive hydroxyapatite (HA) is a common bioceramic that attaches to living tissues in vivo at body temperature. Sol-gel processes are now being used to produce bioactive coatings, powders, and substrates that can facilitate control over biological behavior of proteins and cells with broad clinical applications. It has been found that HA particles can down-regulate the expression of some cancerogenic genes in 432tumor cells. The nano-HA particles from the biodegradation of HA ceramics could penetrate the membranes of tumor cells. A rapid and economic sol-gel method has been designed to synthesize sodium silicate (Na2SiO3) into silica gel in large quantities. Sol-gel-based bioceramics have the potential to present unexpected excellent biological functions. Thus, the understanding and control of the interactions between bioceramics and biological entities may play one of the leading roles in the development of nanomedicine.
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U2 - 10.1201/9781315163598-14
DO - 10.1201/9781315163598-14
M3 - Chapter
AN - SCOPUS:85052476639
SN - 9789814774307
SP - 431
EP - 442
BT - Smart Ceramics
PB - Pan Stanford Publishing Pte. Ltd.
ER -