Solvent effects in 5-deazaflavin oxidation as a model for NAD+ dependent enzymes

Seiji Shinkai, Hideo Kuroda, Osamu Manabe

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

The oxidation rate of 3,5-di-t-butylsalicyl alcohol by 3-methyl-10-ethyl-5-deazaisoalloxazine was found to be very sensitive to solvent effect, the rate constant in 99 vol% DMF being greater by a factor of 37 than that in 50:50 (v/v) DMF-water mixed solvent. The result suggests the importance of the aprotic nature of the reaction environment during the oxidation of alcohols by NAD+.

本文言語英語
ページ(範囲)1357-1360
ページ数4
ジャーナルTetrahedron Letters
23
13
DOI
出版ステータス出版済み - 1 1 1982
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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