Soy peptide dietary supplementation increases serum dopamine level and improves cognitive dysfunction in subjects with mild cognitive impairment

Motohiro Maebuchi, Yutaka Kishi, Takashi Koikeda, Shigeki Furuya

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

抄録

The intake of soy peptide preparations composed mainly of di- and tri-peptides (Hinute, Fuji Oil Co.) is reported to modulate the levels of certain neuroactive amino acids in the adult mouse brain. The present study examined the effects of soy peptide supplementation on higher brain function. The subjects were 30 patients with mild cognitive impairment (soy peptide group : mean age : 58.1 ±1.7 years, n = 15, placebo group : 58.9 ±1.8 years, w = 15). Cognitive function was evaluated by the Japanese version of repeatable battery for the assessment of neuropsychological states (RBANS) at two time points ' at baseline and after 8-week dietary supplementation of 8g/day soy peptides or placebo. Soy peptide supplementation significantly improved the delayed memory score and tended to improve immediate memory (score of story memory), compared with placebo. In addition, soy peptide intake significantly increased serum dopamine, which is associated with memory function, compared with the placebo. The results suggest that soy peptide supplementation can improve aging-related cognitive dysfunction.

元の言語英語
ページ(範囲)67-73
ページ数7
ジャーナルJapanese Pharmacology and Therapeutics
41
発行部数1
出版物ステータス出版済み - 2013

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Dietary Supplements
Dopamine
Peptides
Serum
Placebos
Repression (Psychology)
Cognitive Dysfunction
Brain
Short-Term Memory
Cognition
Oils
Age Groups
Amino Acids

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology

これを引用

Soy peptide dietary supplementation increases serum dopamine level and improves cognitive dysfunction in subjects with mild cognitive impairment. / Maebuchi, Motohiro; Kishi, Yutaka; Koikeda, Takashi; Furuya, Shigeki.

:: Japanese Pharmacology and Therapeutics, 巻 41, 番号 1, 2013, p. 67-73.

研究成果: ジャーナルへの寄稿記事

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