SPARC is associated with carcinogenesis of oral squamous epithelium and consistent with cell competition

Tomohiro Yamada, Seiji Ohno, Naoya Kitamura, Eri Sasabe, Tetsuya Yamamoto

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

The matricellular protein, secreted protein acidic and rich in cysteine (SPARC) is thought to be involved in cell competition. The objective of this study is to investigate the role of SPARC in cancerization of oral squamous epithelium. Clinical specimens from 57 pre- and early cancerous lesion, 66 invasive squamous cell carcinoma (SCC) and controls were immunostained with SPARC. Clinical features and SPARC expression were evaluated. Furthermore, effects of SPARC knockdown and overexpression were examined in oral cancer and keratinocyte cell lines. Leukoplakia, carcinoma in situ, and early invasive SCC had more SPARC-positive cells than normal mucous epithelium. However, there were no significant differences between leukoplakia, carcinoma in situ, and early SCC, and there were no correlations between SPARC immunoreactivity and prognosis of invasive oral SCCs. Cell proliferation was down-regulated by SPARC siRNA, and enhanced by SPARC transformed keratinocytes. But SPARC overexpression did not enhance cell migration activity. SPARC is induced by dysplastic cells in the early stage of cancerization, and may improve survival capability, but is not involved in malignancy. SPARC may act to escape from elimination by cell competition.

元の言語英語
ページ(範囲)129-137
ページ数9
ジャーナルMedical Molecular Morphology
48
発行部数3
DOI
出版物ステータス出版済み - 9 14 2015

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Cysteine
Carcinogenesis
Epithelium
Proteins
Leukoplakia
Squamous Cell Carcinoma
Carcinoma in Situ
Keratinocytes
Mouth Neoplasms
Small Interfering RNA
Cell Movement
Cell Proliferation
Cell Line

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology

これを引用

SPARC is associated with carcinogenesis of oral squamous epithelium and consistent with cell competition. / Yamada, Tomohiro; Ohno, Seiji; Kitamura, Naoya; Sasabe, Eri; Yamamoto, Tetsuya.

:: Medical Molecular Morphology, 巻 48, 番号 3, 14.09.2015, p. 129-137.

研究成果: ジャーナルへの寄稿記事

Yamada, Tomohiro ; Ohno, Seiji ; Kitamura, Naoya ; Sasabe, Eri ; Yamamoto, Tetsuya. / SPARC is associated with carcinogenesis of oral squamous epithelium and consistent with cell competition. :: Medical Molecular Morphology. 2015 ; 巻 48, 番号 3. pp. 129-137.
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