Spatially resolved time-course studies of free radical reactions with an EPRI/MRI fusion technique

Fuminori Hyodo, Keiji Yasukawa, Ken Ichi Yamada, Hideo Utsumi

研究成果: ジャーナルへの寄稿学術誌査読

31 被引用数 (Scopus)

抄録

Electron paramagnetic resonance imaging (EPRI) using nitroxyl radicals is a useful technique for visualizing reactive oxygen species (ROS) and the pharmacokinetics of probes. To unambiguously identify anatomical locations, coregistration of EPRI with images obtained by MRI is necessary. In this study the feasibility of performing reliable EPRI/MRI fusion imaging using nitroxyl radical fiducial markers was tested. The pharmacokinetics of the nitroxyl radicals were observed after oral or intravenous administration in C57BL6 mice. To fuse both images, the nitroxyl radical was used as fiducial markers. The EPR and MR images corresponded well and clearly illustrated minimal changes in pharmacokinetics between carbamoyl-PROXYL and carboxy-PROXYL. These results demonstrate that the EPRI/MRI fused imaging technique is useful for investigating in vivo pharmacokinetics and provides unambiguous anatomic details.

本文言語英語
ページ(範囲)938-943
ページ数6
ジャーナルMagnetic Resonance in Medicine
56
4
DOI
出版ステータス出版済み - 10月 2006

!!!All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング

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