Species-specific neuronal localization of kynurenine aminotransferase-2 in the mouse cerebellum

Emma Balog, Gyula Jenei, Levente Gellért, Etsuro Ono, László Vécsei, József Toldi, Zsolt Kis

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

The immunohistochemical pattern of kynurenine aminotransferase-2 (KAT-2) - the key role enzyme in the production of neuroactive and neuroprotective kynurenic acid (KYNA) - was studied in the cerebellum of mice. It is known from literature that KAT-2 is localized mainly in astrocytes in different parts of the cerebrum. Kynurenine aminotransferase (KAT) activity in the cerebellum is relatively low and alternative production routes for KYNA have been described there. Therefore we examined the immunohistochemical pattern of KAT-2 in this part of the brain. Surprisingly, the cellular localization of KAT-2 in mice was proven to be unique; it localized characteristically in Purkinje cells and in some other types of neurons (not identified) but was not found in astrocytes nor microglia. The exclusive neuronal, but not glial localization of KAT-2 in the cerebellum is novel and may be related to its low activity and to the alternative pathways for KYNA production that have been described.

本文言語英語
論文番号104920
ジャーナルNeurochemistry International
142
DOI
出版ステータス出版済み - 1 2021

All Science Journal Classification (ASJC) codes

  • 細胞および分子神経科学
  • 細胞生物学

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