Splenectomy followed by hepatectomy for hepatocellular carcinoma with hypersplenism and portal hypertension caused by macroglobulinemia

Qingjiang Hu, Kazuki Takeishi, Yo Ichi Yamashita, Tetsuo Ikeda, Huanlin Wang, Shinji Itoh, Norifumi Harimoto, Toru Ikegami, Tomoharu Yoshizumi, Hirofumi Kawanaka, Ken Shirabe, Yoshihiko Maehara

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Aim: To describe a patient with hepatocellular carcinoma (HCC), accompanied by hypersplenism and portal hypertension caused by macroglobulinemia, who underwent splenectomy followed by hepatectomy. Case Report: A 74-year-old man was admitted to our Hospital. He had previously developed primary macroglobulinemia, which had been completely cured by chemotherapy. At admission, he had a low platelet count (52×103/μl), and his liver function was impaired. Imaging showed a 5-cm-sized tumor, an esophageal varix, and splenomegaly, but not liver cirrhosis. The patient underwent splenectomy for hypersplenism and portal hypertension; the weight of his spleen was 2,400 g. After splenectomy, his platelet count increased to 259×103/μl and his liver function was improved. He safely underwent hepatectomy for HCC. The patient was discharged 14 days later without morbidity. Conclusion: These findings suggest that hepatectomy following splenectomy for hypersplenism and portal hypertension caused by macroglobulinemia, may effectively cure HCC in patients with liver dysfunction and thrombocytopenia.

元の言語英語
ページ(範囲)4077-4082
ページ数6
ジャーナルAnticancer research
35
発行部数7
出版物ステータス出版済み - 7 1 2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Hu, Q., Takeishi, K., Yamashita, Y. I., Ikeda, T., Wang, H., Itoh, S., Harimoto, N., Ikegami, T., Yoshizumi, T., Kawanaka, H., Shirabe, K., & Maehara, Y. (2015). Splenectomy followed by hepatectomy for hepatocellular carcinoma with hypersplenism and portal hypertension caused by macroglobulinemia. Anticancer research, 35(7), 4077-4082.